Division for Molecular Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Department of Pathology, Oslo University Hospital, Rikshopitalet, Oslo, Norway.
Scand J Immunol. 2020 Nov;92(5):e12956. doi: 10.1111/sji.12956. Epub 2020 Sep 19.
In a healthy person, metabolically quiescent T lymphocytes (T cells) circulate between lymph nodes and peripheral tissues in search of antigens. Upon infection, some T cells will encounter cognate antigens followed by proliferation and clonal expansion in a context-dependent manner, to become effector T cells. These events are accompanied by changes in cellular metabolism, known as metabolic reprogramming. The magnitude and variation of metabolic reprogramming are, in addition to antigens, dependent on factors such as nutrients and oxygen to ensure host survival during various diseases. Herein, we describe how metabolic programmes define T cell subset identity and effector functions. In addition, we will discuss how metabolic programs can be modulated and affect T cell activity in health and disease using cancer and autoimmunity as examples.
在健康个体中，代谢静止的 T 淋巴细胞（T 细胞）在淋巴结和外周组织之间循环，以寻找抗原。在感染时，一些 T 细胞将遇到同源抗原，随后以依赖于上下文的方式增殖和克隆扩增，成为效应 T 细胞。这些事件伴随着细胞代谢的变化，称为代谢重编程。除了抗原外，代谢重编程的幅度和变化还取决于营养物质和氧气等因素，以确保宿主在各种疾病中存活。在此，我们描述了代谢程序如何定义 T 细胞亚群的特性和效应功能。此外，我们将讨论如何使用癌症和自身免疫性疾病作为示例，通过调节代谢程序来影响 T 细胞在健康和疾病中的活性。
