Department of Immunology and Microbiology, Shanghai JiaoTong University School of Medicine, Shanghai Institute of Immunology, Shanghai, China.
Front Immunol. 2020 Jul 28;11:1668. doi: 10.3389/fimmu.2020.01668. eCollection 2020.
Rheumatoid arthritis (RA) is a common autoimmune disease with characteristics of synovial inflammation, pannus formation, cartilage destruction, and bone erosion. Further, the inflammation is linked to increased oxygen consumption, resulting in hypoxia within the inflammatory area. Hypoxia-inducible factor (HIF) was reported to be associated with adaptation to the hypoxic microenvironment in the RA synovium. Here, we have briefly summarized the structure and expression of HIF. Moreover, the function of HIF in inflammation, angiogenesis, cartilage damage, and immune cells of RA has been discussed.
类风湿关节炎（RA）是一种常见的自身免疫性疾病，其特征为滑膜炎症、血管翳形成、软骨破坏和骨质侵蚀。此外，炎症与耗氧量增加有关，导致炎症区域缺氧。缺氧诱导因子（HIF）被报道与 RA 滑膜中对低氧微环境的适应有关。在这里，我们简要总结了 HIF 的结构和表达。此外，还讨论了 HIF 在 RA 炎症、血管生成、软骨损伤和免疫细胞中的功能。
