Vega Almudena, Quiroga Borja, Abad Soraya, Ruiz Caridad, López-Gómez Juan M
Nefrologia. 2014;34(5):579-83. doi: 10.3265/Nefrologia.pre2014.Jun.12422.
Patients with chronic kidney disease receiving haemodialysis (HD) have permanent variations in hydration status that may affect their survival.
To analyse hydration status and body composition in patients on haemodialysis and its relation to inflammation.
We included 128 prevalent clinically stable patients on haemodialysis. We analysed body composition using spectroscopic bioimpedance and inflammation using blood parameters.
Patients with higher lean tissue had less intracellular (p=0.02) and extracellular water (p = 0.001). We did not find association with fat tissue and hydration. Mean overhydration was 7.5 %. We found an association between overhydration adjusted to extracellular water (OH/ECW) higher than 15 % similar to 10 %. They were both associated with low prealbumin levels (p = 0.001 and p = 0.05 respectively) and low levels of fat tissue (p = 0.001 and p = 0.05 respectively).
Overhydration defined as OH/ECW higher than 10 % and 15 % are related to low prealbumin levels and low fat tissue. We suggest decreasing the overhydration limit measured by bioimpedance to OH/ECW higher than 10 %.
接受血液透析（HD）的慢性肾脏病患者的水合状态存在永久性变化，这可能会影响他们的生存。
分析血液透析患者的水合状态和身体成分及其与炎症的关系。
我们纳入了128例临床稳定的维持性血液透析患者。我们使用光谱生物阻抗分析身体成分，使用血液参数分析炎症情况。
瘦组织较多的患者细胞内（p = 0.02）和细胞外水（p = 0.001）较少。我们未发现脂肪组织与水合之间存在关联。平均水过多为7.5%。我们发现校正细胞外水后的水过多（OH/ECW）高于15%与10%存在关联。它们均与前白蛋白水平低（分别为p = 0.001和p = 0.05）和脂肪组织水平低（分别为p = 0.001和p = 0.05）相关。
定义为OH/ECW高于10%和15%的水过多与前白蛋白水平低和脂肪组织少有关。我们建议将生物阻抗测量的水过多限值降低至OH/ECW高于10%。
