Miyake Masahiro, Yamashiro Kenji, Akagi-Kurashige Yumiko, Oishi Akio, Tsujikawa Akitaka, Hangai Masanori, Yoshimura Nagahisa
Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
PLoS One. 2014 Sep 26;9(9):e107923. doi: 10.1371/journal.pone.0107923. eCollection 2014.
To evaluate fundus shape in highly myopic eyes using color maps created through optical coherence tomography (OCT) image analysis.
We retrospectively evaluated 182 highly myopic eyes from 113 patients. After obtaining 12 lines of 9-mm radial OCT scans with the fovea at the center, the Bruch's membrane line was plotted and its curvature was measured at 1-µm intervals in each image, which was reflected as a color topography map. For the quantitative analysis of the eye shape, mean absolute curvature and variance of curvature were calculated.
The color maps allowed staphyloma visualization as a ring of green color at the edge and as that of orange-red color at the bottom. Analyses of mean and variance of curvature revealed that eyes with myopic choroidal neovascularization tended to have relatively flat posterior poles with smooth surfaces, while eyes with chorioretinal atrophy exhibited a steep, curved shape with an undulated surface (P<0.001). Furthermore, eyes with staphylomas and those without clearly differed in terms of mean curvature and the variance of curvature: 98.4% of eyes with staphylomas had mean curvature ≥7.8×10-5 [1/µm] and variance of curvature ≥0.26×10-8 [1/µm].
We established a novel method to analyze posterior pole shape by using OCT images to construct curvature maps. Our quantitative analysis revealed that fundus shape is associated with myopic complications. These values were also effective in distinguishing eyes with staphylomas from those without. This tool for the quantitative evaluation of eye shape should facilitate future research of myopic complications.
利用光学相干断层扫描（OCT）图像分析创建的彩色地图评估高度近视眼的眼底形态。
我们回顾性评估了113例患者的182只高度近视眼。以黄斑中心凹为中心获取9毫米径向OCT扫描的12条线，绘制出布鲁赫膜线，并在每张图像中以1微米的间隔测量其曲率，这反映为彩色地形图。为了对眼睛形状进行定量分析，计算了平均绝对曲率和曲率方差。
彩色地图可将葡萄肿显示为边缘的绿色环和底部的橙红色环。曲率均值和方差分析显示，患有近视性脉络膜新生血管的眼睛后极相对平坦且表面光滑，而患有脉络膜视网膜萎缩的眼睛呈现陡峭的弯曲形状且表面起伏不平（P<0.001）。此外，有葡萄肿的眼睛和没有葡萄肿的眼睛在平均曲率和曲率方差方面存在明显差异：98.4%有葡萄肿的眼睛平均曲率≥7.8×10-5 [1/微米]且曲率方差≥0.26×10-8 [1/微米]。
我们建立了一种通过使用OCT图像构建曲率图来分析后极形状的新方法。我们的定量分析表明眼底形态与近视并发症有关。这些值在区分有葡萄肿的眼睛和没有葡萄肿的眼睛方面也很有效。这种用于眼睛形状定量评估的工具应有助于未来对近视并发症的研究。
