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妊娠期高血压疾病的管理

Management of hypertensive disorders in pregnancy.

作者信息

Moussa Hind N, Arian Sara E, Sibai Baha M

机构信息

Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology & Reproductive Sciences, The University of Texas Medical School at Houston, 6431 Fannin, Suite 3.430, Houston, TX 77030, USA.

出版信息

Womens Health (Lond). 2014 Jul;10(4):385-404. doi: 10.2217/whe.14.32.

Abstract

Hypertensive disorders are the most common medical complication of pregnancy, with an incidence of 5-10%, and a common cause of maternal mortality in the USA. Incidence of pre-eclampsia has increased by 25% in the past two decades. In addition to being among the lethal triad, there are likely up to 100 other women who experience 'near miss' significant maternal morbidity that stops short of death for every pre-eclampsia-related mortality. The purpose of this review is to present the new task force statement and novel definitions, as well as management approaches to each of the hypertensive disorders in pregnancy. The increased understanding of the pathophysiology of hypertension in pregnancy, as well as advances in medical therapy to minimize risks of fetal toxicity and teratogenicity, will improve our ability to prevent and treat hypertension in pregnancy. Fetal programming and fetal origins of adult disease theories extrapolate the benefit of such therapy to future generations.

摘要

高血压疾病是妊娠期最常见的医学并发症,发病率为5% - 10%,是美国孕产妇死亡的常见原因。在过去二十年中,先兆子痫的发病率增加了25%。除了是致死三联征之一外,每发生一例与先兆子痫相关的孕产妇死亡,可能还有多达100名妇女经历“险些死亡”的严重孕产妇发病情况,但未导致死亡。本综述的目的是介绍新的工作组声明和新定义,以及妊娠期每种高血压疾病的管理方法。对妊娠期高血压病理生理学的进一步了解,以及在医学治疗方面的进展以尽量降低胎儿毒性和致畸性风险,将提高我们预防和治疗妊娠期高血压的能力。胎儿编程和成人疾病的胎儿起源理论将这种治疗的益处延伸到了后代。

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