端粒酶逆转录酶（ALT）通过借鉴减数分裂来实现移动。
ALT telomeres borrow from meiosis to get moving.
作者信息
Arnoult Nausica, Karlseder Jan
机构信息
The Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
The Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
出版信息
Cell. 2014 Sep 25;159(1):11-12. doi: 10.1016/j.cell.2014.09.013.
Abstract
Telomere clustering is required for the homologous recombination events that maintain chromosome ends in cells relying on alternative lengthening of telomeres (ALT). New data demonstrate that damage signaling at telomeres, a likely step in activating maintenance mechanisms, induces directional movement and synapsis driven by the machinery responsible for recombination in meiosis.
摘要
端粒聚集是依赖端粒替代延长（ALT）来维持染色体末端的细胞中同源重组事件所必需的。新数据表明，端粒处的损伤信号传导（这可能是激活维持机制的一个步骤）会诱导由减数分裂中负责重组的机制驱动的定向移动和联会。
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本文引用的文献
1
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Cell. 2014 Sep 25;159(1):108-121. doi: 10.1016/j.cell.2014.08.030.
2
HOP2-MND1 modulates RAD51 binding to nucleotides and DNA.HOP2-MND1调节RAD51与核苷酸和DNA的结合。
Nat Commun. 2014 Jun 19;5:4198. doi: 10.1038/ncomms5198.
3
Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1.通过耗尽组蛋白伴侣 ASF1 快速诱导端粒的替代性延长。
Nat Struct Mol Biol. 2014 Feb;21(2):167-74. doi: 10.1038/nsmb.2754. Epub 2014 Jan 12.
4
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma.组蛋白 H3.3 和染色质重塑基因中的驱动突变与儿童弥漫性脑桥胶质瘤。
Nature. 2012 Jan 29;482(7384):226-31. doi: 10.1038/nature10833.
5
Altered telomeres in tumors with ATRX and DAXX mutations.肿瘤中 ATRX 和 DAXX 突变导致端粒改变。
Science. 2011 Jul 22;333(6041):425. doi: 10.1126/science.1207313. Epub 2011 Jun 30.
6
Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions.在不存在染色体融合的情况下端粒DNA损伤反应的自发发生。
Nat Struct Mol Biol. 2009 Dec;16(12):1244-51. doi: 10.1038/nsmb.1725. Epub 2009 Nov 22.
7
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Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15726-31. doi: 10.1073/pnas.0907689106. Epub 2009 Aug 26.
8
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Nature. 2008 Nov 27;456(7221):524-8. doi: 10.1038/nature07433. Epub 2008 Oct 19.
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