Joshi Monica, Cetroni Bryan, Camacho Amanda, Krueger Clinton, Midey Anthony J
Department of Chemistry, West Chester University of Pennsylvania, 750 South Church St., Schmucker Science South, West Chester, PA 19383, United States.
Department of Chemistry, West Chester University of Pennsylvania, 750 South Church St., Schmucker Science South, West Chester, PA 19383, United States.
Forensic Sci Int. 2014 Nov;244:196-206. doi: 10.1016/j.forsciint.2014.08.033. Epub 2014 Sep 6.
Synthetic cathinones are a class of designer drugs that have captured the attention of researchers and law enforcement agencies around the world. Driven by heightening legal restrictions, this class of drugs now encompasses a large number of psychoactive substances. The detection and characterization of these drugs is complicated by the ever-growing size of the cathinone family. This has fueled the development of unambiguous identification of these drugs in various matrices. There are, however, very few methods reported for improving presumptive screening of seized materials. In this paper, we evaluate the performance of the standard (63)Ni ionization ion mobility spectrometry (IMS) technique for the screening and identification of representative cathinones and associated psychoactive compounds. We discuss the effectiveness of the instrument as a screening tool for cathinones by the analyses of 13 typical cathinone products marketed as "bath salts". Our results show that the ion mobility spectrometer is an acceptable rapid and efficient screening tool for cathinones, positively detecting at least one cathinone in 77% of the samples tested. In addition, we describe an electrospray ionization (ESI) high performance IMS (HPIMS) method for these compounds. The method offers advantages in direct sample ionization and higher resolution. Mass spectrometry (MS) coupled to the HPIMS technique gives the added benefit of identification of ion peaks in products with mixtures of closely related cathinones.
合成卡西酮是一类新型毒品，已引起全球研究人员和执法机构的关注。在日益严格的法律限制推动下，这类毒品现在涵盖了大量精神活性物质。卡西酮家族规模不断扩大，使得对这些毒品的检测和特性分析变得复杂。这推动了在各种基质中对这些毒品进行明确鉴定方法的发展。然而，报道的用于改进对查获材料进行推定筛查的方法非常少。在本文中，我们评估了标准的（63）镍电离离子迁移谱（IMS）技术对代表性卡西酮及相关精神活性化合物的筛查和鉴定性能。我们通过分析13种作为“浴盐”销售的典型卡西酮产品，讨论了该仪器作为卡西酮筛查工具的有效性。我们的结果表明，离子迁移谱仪是一种可接受的用于卡西酮的快速高效筛查工具，在77%的测试样品中能阳性检测出至少一种卡西酮。此外，我们描述了一种用于这些化合物的电喷雾电离（ESI）高效离子迁移谱（HPIMS）方法。该方法在直接样品电离和更高分辨率方面具有优势。与HPIMS技术联用的质谱（MS）能额外鉴定出含有密切相关卡西酮混合物产品中的离子峰。
