Lee Do Hyun, Oh In Young, Koo Kyo Tan, Suk Jang Mi, Jung Sang Wook, Park Jin Oh, Kim Beom Joon, Choi Yoo Mi
Nutrex Technology R&D Center , Seoul , South Korea.
J Cosmet Laser Ther. 2015 Feb;17(1):20-3. doi: 10.3109/14764172.2014.968577. Epub 2014 Oct 27.
Skin aging is accompanied by wrinkle formation. At some sites, such as the periorbital skin, this is a relatively early phenomenon.
We evaluated the anti-wrinkle effect of a preparation containing human growth factor and hyaluronic acid serum on periorbital wrinkles (crow's feet).
In total, 23 Korean women (age range: 39-59 years), who were not pregnant, nursing, or undergoing any concurrent therapy, were enrolled in this study. All the patients completed an 8-week trial of twice-daily application of human growth factor and hyaluronic acid serum on the entire face. Efficacy was based on a global photodamage score, photographs, and image analysis using replicas and visiometer analysis every 4 weeks. The standard wrinkle and roughness parameters used in assessing skin by visiometer were calculated and statistically analyzed.
Periorbital wrinkles were significantly improved after treatment, with improvements noted both by physician's assessment and visiometer analysis.
Topical application of human growth factor and hyaluronic acid was beneficial in reducing periorbital wrinkles.
皮肤老化伴随着皱纹形成。在某些部位，如眼周皮肤，这是一种相对较早出现的现象。
我们评估了一种含人生长因子和透明质酸血清的制剂对眼周皱纹（鱼尾纹）的抗皱效果。
本研究共纳入23名韩国女性（年龄范围：39 - 59岁），她们未怀孕、未哺乳且未接受任何同时进行的治疗。所有患者完成了一项为期8周的试验，每天两次在全脸涂抹人生长因子和透明质酸血清。疗效基于总体光损伤评分、照片以及每4周使用复制品进行的图像分析和皮肤表面粗糙度仪分析。计算并统计分析了使用皮肤表面粗糙度仪评估皮肤时所用的标准皱纹和粗糙度参数。
治疗后眼周皱纹有显著改善，医生评估和皮肤表面粗糙度仪分析均显示出改善。
局部应用人生长因子和透明质酸有助于减少眼周皱纹。
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