Hussain Mussarrat, Phelps Robert, Goldberg David J
Skin Laser and Surgery Specialists of New York and New Jersey, New York, NY 10022, USA.
J Cosmet Laser Ther. 2008 Jun;10(2):104-9. doi: 10.1080/14764170701885392.
The present study reports the clinical, histologic, and ultrastructural changes observed after the 6-month application of a novel skin cream containing a mixture of human growth factors and cytokines. Participants were asked to apply the human growth factor and cytokine skin cream twice daily to their entire face over a period of 6 months. A 3-mm punch biopsy was taken from the preauricular skin area before and after the treatment period. Further evaluations included photographic and clinical assessment of facial skin for wrinkles. After the treatment period, improved clinical appearance of periorbital and perioral wrinkles by 33% and 25% on average, respectively, was demonstrated. Histologic evaluation indicated moderate changes in the epidermal thickness as well as an increased fibroblast density in the superficial dermis at the end of the 6-month treatment period. Ultrastructural changes consistent with new collagen formation were shown by electron microscopy. This study, together with earlier studies, corroborates that topical application of growth factors and cytokines are beneficial in reducing signs of facial skin aging.
本研究报告了一种含有多种人类生长因子和细胞因子混合物的新型护肤霜在使用6个月后观察到的临床、组织学和超微结构变化。参与者被要求在6个月的时间里，每天两次将含有人类生长因子和细胞因子的护肤霜涂抹于全脸。在治疗期前后，从耳前皮肤区域取3毫米的打孔活检组织。进一步的评估包括对面部皮肤皱纹进行拍照和临床评估。治疗期结束后，眶周和口周皱纹的临床表现平均分别改善了33%和25%。组织学评估表明，在6个月治疗期结束时，表皮厚度有中度变化，真皮浅层的成纤维细胞密度增加。电子显微镜显示了与新胶原形成一致的超微结构变化。本研究与早期研究共同证实，局部应用生长因子和细胞因子有助于减少面部皮肤衰老迹象。
