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定制用于皮肤抗衰的生物材料。

Tailoring biomaterials for skin anti-aging.

作者信息

Dan Xin, Li Songjie, Chen Han, Xue Ping, Liu Bo, Ju Yikun, Lei Lanjie, Li Yang, Fan Xing

机构信息

Department of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.

Department of Plastic and Aesthetic (Burn) Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.

出版信息

Mater Today Bio. 2024 Aug 28;28:101210. doi: 10.1016/j.mtbio.2024.101210. eCollection 2024 Oct.

DOI:10.1016/j.mtbio.2024.101210
PMID:39285945
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11402947/
Abstract

Skin aging is the phenomenon of degenerative changes in the structure and function of skin tissues over time and is manifested by a gradual loss of skin elasticity and firmness, an increased number of wrinkles, and hyperpigmentation. Skin anti-aging refers to a reduction in the skin aging phenomenon through medical cosmetic technologies. In recent years, new biomaterials have been continuously developed for improving the appearance of the skin through mechanical tissue filling, regulating collagen synthesis and degradation, inhibiting pigmentation, and repairing the skin barrier. This review summarizes the mechanisms associated with skin aging, describes the biomaterials that are commonly used in medical aesthetics and their possible modes of action, and discusses the application strategies of biomaterials in this area. Moreover, the synergistic effects of such biomaterials and other active ingredients, such as stem cells, exosomes, growth factors, and antioxidants, on tissue regeneration and anti-aging are evaluated. Finally, the possible challenges and development prospects of biomaterials in the field of anti-aging are discussed, and novel ideas for future innovations in this area are summarized.

摘要

皮肤老化是皮肤组织的结构和功能随时间发生退行性变化的现象，表现为皮肤弹性和紧致度逐渐丧失、皱纹增多以及色素沉着。皮肤抗老化是指通过医学美容技术减少皮肤老化现象。近年来，不断开发出新的生物材料，通过机械组织填充、调节胶原蛋白合成与降解、抑制色素沉着以及修复皮肤屏障来改善皮肤外观。本综述总结了与皮肤老化相关的机制，描述了医学美容中常用的生物材料及其可能的作用方式，并讨论了生物材料在该领域的应用策略。此外，还评估了此类生物材料与其他活性成分（如干细胞、外泌体、生长因子和抗氧化剂）对组织再生和抗老化的协同作用。最后，讨论了生物材料在抗老化领域可能面临的挑战和发展前景，并总结了该领域未来创新的新思路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6223/11402947/010ee90d4bfa/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6223/11402947/207a9b32450c/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6223/11402947/418a6fdd284f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6223/11402947/cd1f198d6455/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6223/11402947/d3de20248d43/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6223/11402947/b0f7508103e4/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6223/11402947/ed2e54e0d94b/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6223/11402947/674e1e1666be/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6223/11402947/d5985e35d86c/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6223/11402947/3dd8b58fbf16/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6223/11402947/010ee90d4bfa/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6223/11402947/207a9b32450c/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6223/11402947/418a6fdd284f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6223/11402947/cd1f198d6455/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6223/11402947/d3de20248d43/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6223/11402947/b0f7508103e4/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6223/11402947/ed2e54e0d94b/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6223/11402947/674e1e1666be/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6223/11402947/d5985e35d86c/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6223/11402947/3dd8b58fbf16/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6223/11402947/010ee90d4bfa/gr9.jpg

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ACS Nano. 2024 Jul 22. doi: 10.1021/acsnano.4c01406.
2
Stem Cell-Derived Extracellular Vesicle-Bearing Injectable Hydrogel for Collagen Generation in Dermis.基于干细胞衍生的细胞外囊泡的可注射水凝胶在真皮中促进胶原生成。
ACS Appl Mater Interfaces. 2024 Jul 24;16(29):37698-37706. doi: 10.1021/acsami.4c07434. Epub 2024 Jul 9.
3
Combined multilevel anti-aging strategies and practical applications of dermocosmetics in aesthetic procedures.
Mater Today Bio. 2025 Feb 26;31:101618. doi: 10.1016/j.mtbio.2025.101618. eCollection 2025 Apr.
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J Eur Acad Dermatol Venereol. 2024 Jul;38 Suppl 4:23-35. doi: 10.1111/jdv.19975.
4
New Regenerative and Anti-Aging Medicine Approach Based on Single-Stranded Alpha-1 Collagen for Neo-Collagenesis Induction: Clinical and Instrumental Experience of a New Injective Polycomponent Formulation for Dermal Regeneration.基于单链α-1胶原蛋白诱导新胶原形成的新型再生与抗衰医学方法：一种用于皮肤再生的新型注射多组分制剂的临床与仪器应用经验
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5
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6
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7
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