Surrey E S, Cedars M I
Department of Obstetrics and Gynecology, University of California, Los Angeles School of Medicine.
Fertil Steril. 1989 Jul;52(1):36-41. doi: 10.1016/s0015-0282(16)60785-9.
Ovulation induction in patients with hypergonadotropic premature ovarian failure is rarely successful. The authors have attempted to reproduce the results of recent case reports that suggest that ovulation and pregnancy can be successfully achieved when estrogen therapy precedes or coincides with ovarian stimulation with human menopausal gonadotropins (hMG). Fourteen patients with idiopathic premature ovarian failure underwent gonadotropin suppression and attempted ovulation induction with at least one of three regimens, which were as follows: 1) Group A: estrogen-induced suppression followed by hMG stimulation (n = 4). 2) Group B: estrogen-induced suppression followed by hMG stimulation with concomitant estrogen therapy (n = 10). 3) Group C: gonadotropin-releasing hormone agonist-induced gonadotropin suppression followed by concomitant hMG stimulation (n = 6). Despite complete gonadotropin suppression and high-dose hMG therapy in all three groups, ovulation occurred in only a single patient in group C. Pregnancy did not ensue. These data fail to corroborate previous case reports.
高促性腺激素性卵巢早衰患者的促排卵治疗很少成功。作者试图重现近期病例报告的结果，这些报告表明，在使用人绝经期促性腺激素（hMG）进行卵巢刺激之前或同时进行雌激素治疗时，可以成功实现排卵和妊娠。14例特发性卵巢早衰患者接受了促性腺激素抑制治疗，并尝试采用以下三种方案中的至少一种进行促排卵：1）A组：雌激素诱导抑制，随后进行hMG刺激（n = 4）。2）B组：雌激素诱导抑制，随后进行hMG刺激并同时进行雌激素治疗（n = 10）。3）C组：促性腺激素释放激素激动剂诱导促性腺激素抑制，随后进行hMG刺激（n = 6）。尽管三组均进行了完全的促性腺激素抑制和高剂量hMG治疗，但仅C组有1例患者排卵。未发生妊娠。这些数据未能证实先前的病例报告。
