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在预测老年创伤患者死亡率方面,纳入合并症的模型是否比纳入生命体征和损伤模式的模型表现更优?

Do models incorporating comorbidities outperform those incorporating vital signs and injury pattern for predicting mortality in geriatric trauma?

作者信息

Brooks Steven E, Mukherjee Kaushik, Gunter Oliver L, Guillamondegui Oscar D, Jenkins Judith M, Miller Richard S, May Addison K

机构信息

Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, TN.

Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, TN.

出版信息

J Am Coll Surg. 2014 Nov;219(5):1020-7. doi: 10.1016/j.jamcollsurg.2014.08.001. Epub 2014 Aug 6.

Abstract

BACKGROUND

Geriatric trauma is becoming a significant public health concern. The most commonly used prediction models for mortality benchmarking are based on vital signs and injury pattern, including the Trauma and Injury Severity Score (TRISS), which is less accurate in the elderly. The ICD-9-based prediction models incorporating injuries and comorbidities, such as the University Health System Consortium Expected Mortality (UHC-EM), may be more accurate for the elderly.

STUDY DESIGN

We retrospectively studied all trauma admissions from January 2005 to June 2012 at an academic level I adult trauma center. This was an observational study comparing expected to actual in-hospital mortality for both geriatric (age ≥65 years) and nongeriatric populations. Predictive ability for TRISS and UHC-EM was determined by the area under the receiver operator characteristic curve (AUC).

RESULTS

Geriatric patients had higher median TRISS predicted mortality (8.4% [interquartile range (IQR) 4.8%, 27.4%] vs 2.8% [IQR 1.1%, 30.2%], p < 0.001). Geriatric patients had a median UHC-EM 5 times higher than nongeriatric patients (5.0% [IQR 1.0%, 19.0%] vs 1.0% [IQR 0%, 7.0%], p < 0.001). In-hospital mortality was 3 times higher in geriatric patients (18.1% vs 6.0%, p < 0.001). The UHC-EM had superior AUC to TRISS in both geriatric (0.89 [95% CI 0.87, 0.91] vs 0.81 [95% CI 0.78, 0.84], p < 0.05) and nongeriatric (0.93 [95% CI 0.92, 0.94] vs 0.90 [95% CI 0.89, 0.91], p < 0.05) patients.

CONCLUSIONS

An ICD-9-based algorithm, such as the UHC-EM, which incorporates injuries and comorbidities, may be superior to algorithms based on vital signs and injury patterns without comorbidities in predicting mortality after trauma in the geriatric population.

摘要

背景

老年创伤正成为一个重大的公共卫生问题。最常用的死亡率基准预测模型基于生命体征和损伤模式,包括创伤和损伤严重程度评分(TRISS),但该模型在老年人中准确性较低。基于国际疾病分类第九版(ICD - 9)且纳入损伤和合并症的预测模型,如大学卫生系统联盟预期死亡率(UHC - EM),对老年人可能更准确。

研究设计

我们回顾性研究了2005年1月至2012年6月在一家一级学术成人创伤中心的所有创伤入院病例。这是一项观察性研究,比较老年(年龄≥65岁)和非老年人群的预期与实际住院死亡率。通过受试者操作特征曲线下面积(AUC)来确定TRISS和UHC - EM的预测能力。

结果

老年患者的TRISS预测死亡率中位数更高(8.4% [四分位间距(IQR)4.8%,27.4%] 对比2.8% [IQR 1.1%,30.2%],p < 0.001)。老年患者的UHC - EM中位数比非老年患者高5倍(5.0% [IQR 1.0%,19.0%] 对比1.0% [IQR 0%,7.0%],p < 0.001)。老年患者的住院死亡率高出3倍(18.1%对比6.0%,p < 0.001)。在老年患者(0.89 [95%置信区间0.87,0.91] 对比0.81 [95%置信区间0.78,0.84],p < 0.05)和非老年患者(0.93 [95%置信区间0.92,0.94] 对比0.90 [95%置信区间0.89,0.91],p < 0.05)中,UHC - EM的AUC均优于TRISS。

结论

基于ICD - 9的算法,如UHC - EM,其纳入了损伤和合并症,在预测老年人群创伤后死亡率方面可能优于基于生命体征和无合并症损伤模式的算法。

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