充分的血液透析通过增强终末期肾病患者的葡萄糖-6-磷酸脱氢酶活性来改善贫血。

Adequate hemodialysis improves anemia by enhancing glucose-6-phosphate dehydrogenase activity in patients with end-stage renal disease.

作者信息

Ayesh Haj Yousef Mahmoud Husni, Bataineh Ahnaf, Elamin Elham, Khader Yousef, Alawneh Khaldoon, Rababah Mohamad

机构信息

Department of Internal Medicine, King Abdullah University Hospital, Faculty of Medicine, Jordan University of Science and Technology, P,O, Box 3030, Irbid 22110, Jordan.

出版信息

BMC Nephrol. 2014 Sep 26;15:155. doi: 10.1186/1471-2369-15-155.

DOI:10.1186/1471-2369-15-155

PMID:25261071

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4181374/

Abstract

BACKGROUND

We conducted this study to determine the erythrocyte glucose-6-phosphate dehydrogenase (G6PD) activity level in patients with end-stage renal disease (ESRD) on maintenance hemodialysis (HD) and to determine the effect of hemodialysis adequacy on G6PD activity levels and its impact on anemia.

METHODS

Eighty-two patients (48 men and 34 women) receiving regular hemodialysis for ESRD through arteriovenous fistulae for at least one year prior to the start of the study were enrolled in this study. G6PD activity levels were measured in all patients and the average Kt/V was used as a parameter of HD adequacy. Patients were divided into two groups according to Kt/V values. Group 1 included 45 patients with Kt/V(˃)1.2 (adequate HD), and group 2 included 37 patients with Kt/V(˃)1.2 (inadequate HD). The average hemoglobin level and the weekly dose of an erythropoietin-stimulating agent, epoetin alpha (ESA), for each patient were calculated for one year.

RESULTS

The mean (SD) erythrocyte G6PD activity for all patients on hemodialysis was 7.64 ± 1.85 U/g Hb. Patients who had received adequate hemodialysis had a significantly higher average erythrocyte G6PD (mean (SD) = 9.2 ± 0.7 U/g Hb) compared to patients who had inadequate hemodialysis (mean (SD) = 5.7 ± 0.7 U/g Hb) (P-value <0.005). The mean hemoglobin concentration was significantly higher in patients with adequate hemodialysis compared to those with inadequate hemodialysis.

CONCLUSION

Our study demonstrated the beneficial effect of adequate hemodialysis in correcting anemia by enhancing the erythrocyte G6PD activity in patients.

摘要

背景

我们开展这项研究，以确定维持性血液透析（HD）的终末期肾病（ESRD）患者的红细胞葡萄糖-6-磷酸脱氢酶（G6PD）活性水平，并确定血液透析充分性对G6PD活性水平的影响及其对贫血的影响。

方法

本研究纳入了82例患者（48例男性和34例女性），这些患者在研究开始前通过动静脉内瘘接受ESRD定期血液透析至少一年。测量所有患者的G6PD活性水平，并将平均Kt/V用作血液透析充分性的参数。根据Kt/V值将患者分为两组。第1组包括45例Kt/V（＞）1.2（血液透析充分）的患者，第2组包括37例Kt/V（≤）1.2（血液透析不充分）的患者。计算每位患者一年的平均血红蛋白水平和促红细胞生成素刺激剂α-促红细胞生成素（ESA）的每周剂量。

结果

所有接受血液透析患者的平均（标准差）红细胞G6PD活性为7.64±1.85 U/g Hb。与血液透析不充分的患者（平均（标准差）=5.7±0.7 U/g Hb）相比，接受充分血液透析的患者平均红细胞G6PD显著更高（平均（标准差）=9.2±0.7 U/g Hb）（P值<0.005）。与血液透析不充分的患者相比，血液透析充分的患者平均血红蛋白浓度显著更高。