胰岛素依赖型糖尿病患者的糖尿病肾病：肾脏血流动力学及衍生的治疗策略

Diabetic nephropathy in insulin-dependent diabetic patients: renal hemodynamics and derived treatment strategies.

作者信息

ter Wee P M, Donker J M

机构信息

Department of Internal Medicine, Free University Hospital, Amsterdam, The Netherlands.

出版信息

J Diabet Complications. 1989 Apr-Jun;3(2):62-9. doi: 10.1016/0891-6632(89)90014-7.

DOI:10.1016/0891-6632(89)90014-7

PMID:2526142

Abstract

Late complications such as retinopathy and neuropathy contribute substantially to the morbidity of patients with diabetes mellitus but have only moderate effect on their life expectancy. However, once diabetic nephropathy occurs, life expectancy of patients with diabetes mellitus is shortened considerably. This review discusses briefly several possible pathogenetic mechanisms involved in the development of diabetic nephropathy. Changes in renal hemodynamics as the initiating and contributing factor to the development of diabetic nephropathy are discussed in more detail. Finally, the article reviews possible therapeutic measures to prevent the development of diabetic nephropathy, or to slow down its progression.

摘要

诸如视网膜病变和神经病变等晚期并发症在很大程度上导致了糖尿病患者的发病，但对其预期寿命的影响仅为中度。然而，一旦发生糖尿病肾病，糖尿病患者的预期寿命会显著缩短。本综述简要讨论了糖尿病肾病发生过程中涉及的几种可能的发病机制。作为糖尿病肾病发生的起始和促成因素的肾脏血流动力学变化将进行更详细的讨论。最后，本文综述了预防糖尿病肾病发生或减缓其进展的可能治疗措施。