Beltrán-Sánchez Hiram, Razak Fahad, Subramanian S V
Center for Demography of Health and Aging, University of Wisconsin-Madison, Madison, WI, USA.
St Michael's Hospital, University of Toronto, Toronto, Canada; Li Ka Shing Knowledge Institute, Ontario, Canada; Harvard Center for Population and Development Studies, Cambridge, MA, USA.
Glob Health Action. 2014 Sep 24;7:24766. doi: 10.3402/gha.v7.24766. eCollection 2014.
As originally proposed by Fries, conceptualizing morbidity solely through associated functional limitation/disability (FL/D) remains the most widely accepted metric to assess whether increases in longevity have been accompanied by a compression of morbidity.
To propose a departure from a highly restrictive FL/D-based definition of "morbidity" to a broader view that considers the burden of chronic diseases even when no overt FL/D occur.
We outline three reasons why the current framework of compression of morbidity should be broadened to also consider morbidity to be present even when there are no overtly measurable FL/D. We discuss various scenarios of morbidity compression and morbidity expansion under this broader rubric of morbidity.
The rationale to go beyond a purely FL/D-based definition of morbidity includes: (1) substantial damage from chronic disease that can develop prior to overt FL/D symptoms occurring; (2) multiple costs to the individual and society that extend beyond FL/D, including medication costs, health care visits, and opportunity costs of lifelong treatment; and (3) psychosocial and stress burden of being labeled as diseased and the consequence for overall well-being. Adopting this broader definition of morbidity suggests that increases in longevity have been possibly accompanied by an expansion of morbidity, in contrast to Fries' original hypothesis that morbidity onset (based on only FL/D) would be delayed to a greater extent than increases in survival. There is an urgent need for better data and more research to document morbidity onset and its link with increases in longevity and assess the important question on whether populations while living longer are also healthier.
正如弗里斯最初所提出的,仅通过相关功能受限/残疾(FL/D)来概念化发病率,仍然是评估寿命延长是否伴随着发病率压缩的最广泛接受的指标。
提出背离基于高度限制性的FL/D对“发病率”的定义,转而采用更广泛的观点,即即使没有明显的FL/D发生,也考虑慢性病的负担。
我们概述了三个原因,说明为何应拓宽当前发病率压缩的框架,以便在没有明显可测量的FL/D时也将发病率视为存在。我们讨论了在这个更广泛的发病率范畴下发病率压缩和发病率扩展的各种情形。
超越基于纯粹FL/D的发病率定义的理由包括:(1)在明显的FL/D症状出现之前,慢性病可能造成的重大损害;(2)对个人和社会的多种成本,这些成本超出了FL/D,包括药物成本、医疗就诊以及终身治疗的机会成本;(3)被贴上患病标签所带来的心理社会和压力负担以及对整体幸福感的影响。采用这种更广泛的发病率定义表明,与弗里斯最初的假设(即基于仅FL/D的发病率发作会比生存率的提高延迟更大程度)相反,寿命延长可能伴随着发病率的扩展。迫切需要更好的数据和更多研究来记录发病率发作及其与寿命延长的联系,并评估关于人群在寿命延长的同时是否也更健康这一重要问题。