Kilic Mehmet, Gündüzalp Mehmet, Taskin Erdal, Aydin Süleyman, Serin Hepsen M
Department of Pediatrics, Faculty of Medicine, University of Firat, Elazig, Turkey -
Minerva Pediatr. 2016 Apr;68(2):127-33. Epub 2014 Sep 29.
In this study we aimed to evaluate the serum levels of Heat-shock protein (Hsp) 70 and acylated and desacylated ghrelin in patients suffering from a simple febrile convulsion.
This cross-sectional study included patients who were diagnosed with a simple febrile convulsion, afebrile tonic-clonic epileptic seizure and upper respiratory tract infection when admitted to our hospital. All patients were aged between six months and 60 months. Patients enrolled in this study were divided into five groups. Group I: patients with a simple febrile convulsion and body temperature of 38º C to 39° C; group II: patients with a simple febrile convulsion and body temperature of 39.1° C to 41° C; group III: patients with primary generalised tonic-clonic seizure and normal body temperature; group IV: patients with upper respiratory infection without convulsion and a body temperature of 38° C to 39° C; and group V: patients with upper respiratory infection without convulsion and a body temperature of 39.1° C to 41° C. The control group included healthy children who were followed up in the healthy children polyclinic. Serum levels of Hsp70 and acylated and des-acylated ghrelin were studied from the blood samples collected from the patients and control group.
Serum levels of Hsp70 were higher in the febrile convulsion (groups I, II) and epileptic convulsion and infection (groups IV, V) groups than in the controls (P<0.0001). Moreover, serum levels of acylated and desacylated ghrelin were higher in the simple febrile convulsion (groups I and II) and epileptic convulsion and infection (groups IV and V) groups than in the control (P<0.05).
We demonstrated that serum levels of Hsp70 and acylated and desacylated ghrelin increased in patients with a simple febrile convulsion.
在本研究中，我们旨在评估单纯性热性惊厥患者血清中热休克蛋白（Hsp）70、酰化和去酰化胃泌素的水平。
这项横断面研究纳入了入院时被诊断为单纯性热性惊厥、无热强直阵挛性癫痫发作和上呼吸道感染的患者。所有患者年龄在6个月至60个月之间。本研究纳入的患者分为五组。第一组：体温在38℃至39℃的单纯性热性惊厥患者；第二组：体温在39.1℃至41℃的单纯性热性惊厥患者；第三组：原发性全身性强直阵挛发作且体温正常的患者；第四组：无惊厥且体温在38℃至39℃的上呼吸道感染患者；第五组：无惊厥且体温在39.1℃至41℃的上呼吸道感染患者。对照组包括在健康儿童门诊接受随访的健康儿童。对从患者和对照组采集的血样进行Hsp70、酰化和去酰化胃泌素血清水平的研究。
热性惊厥组（第一组、第二组）、癫痫性惊厥和感染组（第四组、第五组）的Hsp70血清水平高于对照组（P<0.0001）。此外，单纯性热性惊厥组（第一组和第二组）、癫痫性惊厥和感染组（第四组和第五组）的酰化和去酰化胃泌素血清水平高于对照组（P<0.05）。
我们证明单纯性热性惊厥患者血清中Hsp70、酰化和去酰化胃泌素水平升高。
