Bates Angelina, Shen Qiuhua, Hiebert John B, Thimmesch Amanda, Pierce Janet D
Olathe Cardiology Services, Olathe Medical Center, Olathe, Kansas, USA.
Nurs Health Sci. 2014 Dec;16(4):428-33. doi: 10.1111/nhs.12168. Epub 2014 Sep 28.
Diastolic heart failure, or heart failure with preserved ejection fraction, is a leading cause of morbidity and mortality. There are no current therapies effective in improving outcomes for these patients. The aim of this article is to review the literature and examine the role of coenzyme Q10 in heart failure with preserved ejection fraction related to mitochondrial synthesis of adenosine triphosphate and reactive oxygen species production. The study results reflect that myocardial energetics alters in diastolic heart failure and that there is defective energy metabolism and increased oxidative stress. Studies are emerging to evaluate coenzyme Q10 , particularly ubiquinol, as a supplemental treatment for heart-failure patients. In diastolic heart-failure patients, clinicians are beginning to use supplemental therapies to improve patient outcomes, and one promising complementary treatment to improve left ventricular diastolic function is ubiquinol. Additional studies are needed using large-scale randomized models to confirm if ubiquinol would be beneficial. Since ubiquinol is an antioxidant and is required for adenosine triphosphate production, clinicians and health scientists should be aware of the potential role of this supplement in the treatment of diastolic heart failure.
舒张性心力衰竭，即射血分数保留的心力衰竭，是发病和死亡的主要原因。目前尚无有效改善这些患者预后的治疗方法。本文旨在回顾文献，探讨辅酶Q10在射血分数保留的心力衰竭中与三磷酸腺苷的线粒体合成及活性氧生成相关的作用。研究结果表明，舒张性心力衰竭中心肌能量学发生改变，存在能量代谢缺陷和氧化应激增加。越来越多的研究开始评估辅酶Q10，尤其是泛醇，作为心力衰竭患者的补充治疗。在舒张性心力衰竭患者中，临床医生开始使用补充疗法来改善患者预后，一种有望改善左心室舒张功能的补充治疗方法是泛醇。需要使用大规模随机模型进行更多研究，以证实泛醇是否有益。由于泛醇是一种抗氧化剂，且是三磷酸腺苷生成所必需的，临床医生和健康科学家应意识到这种补充剂在舒张性心力衰竭治疗中的潜在作用。
