Department of Pediatrics, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.
School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.
Nutrients. 2018 Nov 7;10(11):1697. doi: 10.3390/nu10111697.
Pediatric dilated cardiomyopathy (PDCM) is a life-threatening type of cardiac muscle dysfunction in children. Ubiquinone is a lipid-soluble nutrient that participates in energy synthesis. Recently, a novel hydrophilic ubiquinol supplement was developed. The purpose of this study was to assess the effect of liquid ubiquinol supplementation (10 mg/kg body weight/day) on cardiac function in children with PDCM.
Ten children diagnosed with PDCM were recruited to this study and administered with liquid ubiquinol for 24 weeks. The cardiac function was measured by echocardiography. The New York Heart Association (NYHA) functional classification was used to assess symptoms of heart failure. Plasma coenzyme Q10 levels were measured during the study.
Ejection fraction (EF) and fractional shortening (FS) were significantly higher than the baseline values until week 16 of supplementation. Subjects who had higher plasma coenzyme Q10 concentration had significantly better EF and FS values. In addition, 30% of the subjects showed improvement in the NYHA classification after 24 weeks of supplementation.
Liquid ubiquinol supplementation is associated with an increase the level of coenzyme Q10 to complementary improve cardiac function (particularly EF and FS) and ameliorate the symptoms of heart failure in children with PDCM.
小儿扩张型心肌病（PDCM）是一种危及生命的儿童心肌功能障碍。泛醌是一种脂溶性营养素，参与能量合成。最近，开发了一种新型亲水性泛醇补充剂。本研究的目的是评估液体泛醇补充剂（10 毫克/千克体重/天）对 PDCM 患儿心功能的影响。
本研究招募了 10 名诊断为 PDCM 的儿童，并给予液体泛醇治疗 24 周。通过超声心动图测量心功能。纽约心脏协会（NYHA）功能分类用于评估心力衰竭症状。在研究过程中测量血浆辅酶 Q10 水平。
补充剂 16 周前，射血分数（EF）和缩短分数（FS）均显著高于基线值。血浆辅酶 Q10 浓度较高的受试者 EF 和 FS 值显著更好。此外，24 周补充后，30%的受试者 NYHA 分类得到改善。
液体泛醇补充与辅酶 Q10 水平升高有关，可补充改善心功能（尤其是 EF 和 FS），并改善 PDCM 患儿心力衰竭症状。
