Lašaitė Lina, Ostrauskas Rytas, Žalinkevičius Rimantas, Jurgevičienė Nijolė, Radzevičienė Lina
J Pediatr Endocrinol Metab. 2015 Mar;28(3-4):279-85. doi: 10.1515/jpem-2014-0162.
Although diabetes may not be associated with psychopathology, it may be associated with less severe disturbances in psychosocial functioning. Emotional problems in relation to type 1 diabetes are usually analysed as symptoms of psychiatric conditions but not as states of mood. The aim was to compare profiles of mood states in adult patients with childhood-onset and adulthood-onset type 1 diabetes mellitus and to outline possible gender-specific differences.
A total of 214 adult type 1 diabetic patients were randomly selected from the Lithuanian Diabetes Registry. The mood states were compared in 105 (42 men and 63 women) patients with type 1 diabetes diagnosed during 0-18 years of life and in 109 (61 men and 48 women) diagnosed in adulthood. The scores of tension-anxiety, depression-dejection, anger-hostility, vigour-activity, fatigue-inertia and confusion-bewilderment were evaluated using the Profile of Mood States.
Depression-dejection was higher in adulthood-onset diabetic women than in childhood-onset (p=0.005) diabetic patients. In childhood-onset diabetic patients depression-dejection (p=0.046) and confusion-bewilderment (p=0.033) were higher in women than in men. Adulthood-onset women with diabetes had higher tension-anxiety (p=0.027), depression-dejection (p=0.001), and confusion-bewilderment (p=0.004) scores than men. Multiple logistic analyses showed that adulthood-onset period of type 1 diabetes is associated with higher levels of depression-dejection [OR=1.1; 95% confidence intervals (CI) 1.01-1.19, p=0.025], longer diabetes duration (OR=2.00; 95% CI 1.27-2.03, p=0.012), higher HbA1c level (OR=1.15; 95% CI 1.02-1.3, p=0.023), and female gender (OR=2.51; 95% CI 1.29-2.90, p=0.021).
Profile of mood states in adult women with type 1 diabetes is worse than in men. Adulthood-onset type 1 diabetic women have higher depression-dejection than do childhood-onset diabetic patients. Adulthood-onset period of type 1 diabetes is associated with higher levels of depression-dejection, longer diabetes duration and female gender.
虽然糖尿病可能与精神病理学无关，但它可能与心理社会功能中不太严重的紊乱有关。与1型糖尿病相关的情绪问题通常被分析为精神疾病的症状，而不是情绪状态。目的是比较成年期发病和儿童期发病的1型糖尿病成年患者的情绪状态概况，并概述可能存在的性别差异。
从立陶宛糖尿病登记处随机选取214例成年1型糖尿病患者。比较了105例（42名男性和63名女性）0至18岁确诊的1型糖尿病患者和109例（61名男性和48名女性）成年期确诊的患者的情绪状态。使用情绪状态剖面图评估紧张焦虑、抑郁沮丧、愤怒敌意、活力活动、疲劳惰性和困惑迷茫的得分。
成年期发病的糖尿病女性的抑郁沮丧得分高于儿童期发病的（p=0.005）糖尿病患者。在儿童期发病的糖尿病患者中，女性的抑郁沮丧（p=0.046）和困惑迷茫（p=0.033）得分高于男性。成年期发病的糖尿病女性的紧张焦虑（p=0.027）、抑郁沮丧（p=0.001）和困惑迷茫（p=0.004）得分高于男性。多因素逻辑分析显示，1型糖尿病成年期发病与较高水平的抑郁沮丧相关[比值比（OR）=1.1；95%置信区间（CI）1.01-1.19，p=0.025]、糖尿病病程较长（OR=2.00；95%CI 1.27-2.03，p=0.012）、糖化血红蛋白（HbA1c）水平较高（OR=1.15；95%CI 1.02-1.3，p=0.023）以及女性性别（OR=2.51；95%CI 1.29-2.90，p=0.021）。
成年1型糖尿病女性的情绪状态概况比男性差。成年期发病的1型糖尿病女性的抑郁沮丧程度高于儿童期发病的糖尿病患者。1型糖尿病成年期发病与较高水平的抑郁沮丧、较长的糖尿病病程和女性性别相关。
