Zhang Di, Liu Chang-Hong, Zhang Jincai, Cai Dehong, Yang Xiaoyu, Li Shiyi, Zhong Huilan
epartment of Implantology, Affiliated Stomatological Hospital of Southern Medical University/Guangdong Provincial Stomatological Hospital, Guangzhou 510280, China. E-mail:
Nan Fang Yi Ke Da Xue Xue Bao. 2014 Aug;34(9):1386-9.
To investigate the effect of cetylpyridinium chloride buccal tablets on halitosis induced by oral conditions.
With Porphyromonas gingivalis, Prevotella intermedia and Fusobacterium nucleatum as the testing bacteria, the minimal inhibitory concentration (MIC) of cetylpyridinium chloride buccal tablets was determined using minute amount serial dilution test. The production of volatile sulfur compounds (VSCs) was measured using sulfide detector halimeter in the anaerobic bacteria culture at 4 and 8 h after addition of the tablets. The effect of the tablets in suppressing odor production by mouth-borne halitosis bacteria was assessed using cysteine challenge test in healthy volunteers, and the effectiveness was evaluated by measuring the reduction in VSCs production and the duration of the effect.
Cetylpyridinium chloride buccal tablets inhibited the growth of all the 3 bacteria. The tablets obviously inhibited VSCs production by the 3 bacteria with a effect similar to chlorhexidine. Compared with distilled water gargle, the buccal tablets significantly reduced cysteine-induced VSCs production level in the healthy volunteers (P<0.05), and the effect lasted for 230 min.
Cetylpyridinium chloride tablets can obviously suppress bacteria responsible for oral halitosis and produce good effects in the treatment of halitosis induced by oral conditions.
探讨西吡氯铵含片对口腔疾病所致口臭的影响。
以牙龈卟啉单胞菌、中间普氏菌和具核梭杆菌为测试菌，采用微量系列稀释法测定西吡氯铵含片的最低抑菌浓度（MIC）。在加入含片后4小时和8小时，使用硫化物检测仪在厌氧菌培养物中测量挥发性硫化合物（VSC）的产生量。在健康志愿者中采用半胱氨酸激发试验评估含片对口腔源性口臭细菌产生气味的抑制作用，并通过测量VSC产生量的减少和作用持续时间来评估有效性。
西吡氯铵含片可抑制所有3种细菌的生长。该片明显抑制这3种细菌产生VSC，效果与氯己定相似。与蒸馏水漱口相比，含片显著降低了健康志愿者中半胱氨酸诱导的VSC产生水平（P<0.05），且效果持续230分钟。
西吡氯铵含片可明显抑制导致口腔口臭的细菌，对口腔疾病所致口臭的治疗有良好效果。
