Kang Jeong Hyun, Jang Yun Ji, Kim Dae Jeong, Park Ji Woon
Int J Oral Maxillofac Implants. 2015 Nov-Dec;30(6):1341-7. doi: 10.11607/jomi.3824. Epub 2015 Oct 16.
To clarify the antimicrobial efficacy of zinc chloride (ZnCl2) and cetylpyridinium chloride (CPC) by testing their impact on the growth of seven bacterial strains known to be involved in the pathophysiology of both peri-implant disease and halitosis-Staphylococcus aureus, Streptococcus mutans, Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum, Treponema denticola, and Tannerella forsythia.
A time-response growth curve was obtained. Commercial mouthrinses with CPC, ZnCl2, or both were added to the media in a final concentration of 0.25% CPC, 2.5% ZnCl2, and 2.5% ZnCl2 with 0.25% CPC.
Both CPC and ZnCl2 effectively inhibited the growth of almost all bacterial strains tested except T denticola. ZnCl2 was generally more effective in suppressing bacterial growth than CPC. ZnCl2 with CPC showed the greatest inhibitory activities on almost all strains of bacterial growth except for P gingivalis and T denticola, followed by ZnCl2, then CPC, thus suggesting the possibility of a synergistic effect of the two agents. P gingivalis exhibited a different pattern because ZnCl2 showed the most significant inhibitory effect. CPC did not show growth inhibitory effects on T denticola, but ZnCl2 did.
Zinc and CPC effectively inhibit bacterial growth that causes both halitosis and peri-implant disease. The effect is even more powerful when applied in combination.
通过测试氯化锌（ZnCl2）和氯化十六烷基吡啶（CPC）对七种已知与种植体周围疾病和口臭病理生理学相关的细菌菌株生长的影响，来阐明它们的抗菌效果，这七种细菌菌株分别是金黄色葡萄球菌、变形链球菌、牙龈卟啉单胞菌、中间普氏菌、具核梭杆菌、齿垢密螺旋体和福赛坦氏菌。
获得了时间-反应生长曲线。将含有CPC、ZnCl2或两者的市售漱口水以0.25% CPC、2.5% ZnCl2以及2.5% ZnCl2与0.25% CPC的终浓度添加到培养基中。
除齿垢密螺旋体外，CPC和ZnCl2均有效抑制了几乎所有测试细菌菌株的生长。ZnCl2在抑制细菌生长方面通常比CPC更有效。ZnCl2与CPC对几乎所有细菌菌株的生长显示出最大的抑制活性，除了牙龈卟啉单胞菌和齿垢密螺旋体，其次是ZnCl2，然后是CPC，这表明两种药剂可能存在协同作用。牙龈卟啉单胞菌表现出不同的模式，因为ZnCl2显示出最显著的抑制作用。CPC对齿垢密螺旋体未显示出生长抑制作用，但ZnCl2有。
锌和CPC可有效抑制导致口臭和种植体周围疾病的细菌生长。联合应用时效果更强。
