tRNA 的 A-to-I 编辑：生化、生物学和进化意义。

A-to-I editing on tRNAs: biochemical, biological and evolutionary implications.

机构信息

Institute for Research in Biomedicine (IRB Barcelona), C/ Baldiri Reixac 10, Barcelona 08028, Catalonia, Spain.

Institute for Research in Biomedicine (IRB Barcelona), C/ Baldiri Reixac 10, Barcelona 08028, Catalonia, Spain; Catalan Institution for Research and Advanced Studies (ICREA), P/ Lluís Companys 23, Barcelona 08010, Catalonia, Spain.

出版信息

FEBS Lett. 2014 Nov 28;588(23):4279-86. doi: 10.1016/j.febslet.2014.09.025. Epub 2014 Sep 27.

DOI:10.1016/j.febslet.2014.09.025

PMID:25263703

Abstract

Inosine on transfer RNAs (tRNAs) are post-transcriptionally formed by a deamination mechanism of adenosines at positions 34, 37 and 57 of certain tRNAs. Despite its ubiquitous nature, the biological role of inosine in tRNAs remains poorly understood. Recent developments in the study of nucleotide modifications are beginning to indicate that the dynamics of such modifications are used in the control of specific genetic programs. Likewise, the essentiality of inosine-modified tRNAs in genome evolution and animal biology is becoming apparent. Here we review our current understanding on the role of inosine in tRNAs, the enzymes that catalyze the modification and the evolutionary link between such enzymes and other deaminases.

摘要

肌苷在转移 RNA（tRNA）上是通过某些 tRNA 中位置 34、37 和 57 的腺苷脱氨酶机制转录后形成的。尽管肌苷普遍存在，但它在 tRNA 中的生物学作用仍知之甚少。核苷酸修饰研究的最新进展开始表明，这些修饰的动态用于控制特定的遗传程序。同样，在基因组进化和动物生物学中，肌苷修饰的 tRNA 的必要性也变得明显。在这里，我们回顾了我们目前对 tRNA 中肌苷的作用、催化修饰的酶以及这些酶与其他脱氨酶之间的进化联系的理解。