胡齐斯坦牛至精油对四氧嘧啶诱导的糖尿病大鼠抗氧化酶活性改变的改善作用。
Amelioration of altered antioxidant enzyme activity by Satureja khuzistanica essential oil in alloxan-induced diabetic rats.
作者信息
Ahmadvand Hassan
机构信息
Razi Herbal Researches Center, Lorestan University of Medical Sciences, Khoram Abad, Iran; Department of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khoram Abad, Iran.
出版信息
Chin J Nat Med. 2014 Sep;12(9):672-6. doi: 10.1016/S1875-5364(14)60102-3.
AIM
To examine the possible protective effect of Satureja khuzistanica essential oil (SKE) on antioxidant enzyme activity in alloxan-induced Type 1 diabetic rats.
METHOD
Thirty Sprague-Dawley male rats were divided into three groups randomly; group one as control, group two diabetic, with no treatment, and group three treatment with SKE at 500 ppm in drinking water, respectively. Diabetes was induced in the second and third groups by alloxan injection subcutaneously. After eight weeks, animals were anaesthetized. Blood samples were also collected before killing to measure antioxidant enzymes activity.
RESULTS
SKE significantly increased the serum level of glutathione and the serum activity of glutathione peroxidase, superoxide dismutase, and catalase in the treated group compared with the diabetic untreated group.
CONCLUSION
The findings showed that SKE exerts beneficial effects on the antioxidant enzymes activity in alloxan-induced Type 1 diabetic rats.
目的
研究胡齐斯坦牛至精油（SKE）对四氧嘧啶诱导的1型糖尿病大鼠抗氧化酶活性的可能保护作用。
方法
将30只雄性Sprague-Dawley大鼠随机分为三组；第一组为对照组，第二组为糖尿病组，不进行治疗，第三组用饮用水中浓度为500 ppm的SKE进行治疗。第二组和第三组通过皮下注射四氧嘧啶诱导糖尿病。八周后，将动物麻醉。在处死前还采集血样以测量抗氧化酶活性。
结果
与未治疗的糖尿病组相比，SKE显著提高了治疗组的谷胱甘肽血清水平以及谷胱甘肽过氧化物酶、超氧化物歧化酶和过氧化氢酶的血清活性。
结论
研究结果表明，SKE对四氧嘧啶诱导的1型糖尿病大鼠的抗氧化酶活性具有有益作用。
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