Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, Leipzig, Germany.
MerLion Pharmaceuticals GmbH, Berlin, Germany.
Int J Antimicrob Agents. 2014 Nov;44(5):420-3. doi: 10.1016/j.ijantimicag.2014.07.006. Epub 2014 Aug 19.
The activity of finafloxacin against 73 strains of the Bacteroides fragilis group, 10 other Gram-negative anaerobic rods and 31 Clostridium difficile strains was determined by the broth microdilution technique. The activity was compared with that of moxifloxacin, levofloxacin, ciprofloxacin, clindamycin, imipenem, piperacillin/tazobactam and metronidazole. MIC(50/90) values (minimum inhibitory concentration, in μg/mL, at which 50% and 90% of the isolates tested are inhibited, respectively) for finafloxacin for the different species were determined: B. fragilis group, 0.5/2; other Gram-negative rods, 0.06/0.25; and C. difficile, 4/16. Furthermore, the MICs against 11 selected B. fragilis strains were determined under acidic conditions and resulted in MIC(50/90) values for finafloxacin of 0.25/4 μg/mL. Thus, finafloxacin shows promising activity against several pathogenic species of anaerobes. Furthermore, finafloxacin has increased activity against selected B. fragilis strains under acidic conditions compared with activity at neutral pH.
采用肉汤微量稀释法测定了法氟沙星对 73 株脆弱拟杆菌群、10 株其他革兰阴性厌氧杆菌和 31 株艰难梭菌的活性。将其活性与莫西沙星、左氧氟沙星、环丙沙星、克林霉素、亚胺培南、哌拉西林/他唑巴坦和甲硝唑进行了比较。确定了法氟沙星对不同种属的 MIC（50/90）值（以 μg/mL 表示，分别为测试的 50%和 90%分离物被抑制的最小抑菌浓度）：脆弱拟杆菌群为 0.5/2；其他革兰阴性杆菌为 0.06/0.25；艰难梭菌为 4/16。此外，还在酸性条件下测定了 11 株选定的脆弱拟杆菌株的 MIC，结果法氟沙星的 MIC（50/90）值为 0.25/4 μg/mL。因此，法氟沙星对几种致病性厌氧菌具有良好的活性。此外，与中性 pH 时的活性相比，法氟沙星在酸性条件下对选定的脆弱拟杆菌株的活性增加。
