Ackermann G, Schaumann R, Pless B, Claros M C, Goldstein E J, Rodloff A C
Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, Germany.
Eur J Clin Microbiol Infect Dis. 2000 Mar;19(3):228-32. doi: 10.1007/s100960050465.
The antimicrobial activity of moxifloxacin and seven other antibiotics (four of them quinolones) against 292 strains of obligately anaerobic bacteria was assessed employing a broth microdilution technique performed in Wilkens-Chalgren broth. MIC50/MIC90 values (mg/l) for moxifloxacin were as follows: Bacteroides fragilis (n = 62) 0.25/2, Bacteroides ovatus (n = 70) 1/4, Bacteroides vulgatus (n = 29) 0.25/1, Bacteroides thetaiotaomicron (n = 17) 2/2, Bacteroides caccae (n = 11) 1/2, Prevotella spp. (n = 11) 0.25/2, Fusobacterium spp. (n = 17) 1/4, Bilophila wadsworthia (n = 29) 0.5/1, and Clostridium spp. (n = 29) 0.125/0.5, respectively. MIC50 values (mg/l) for Bacteroides distasonis (n = 8) and Peptostreptococcus spp. (n = 9) were 0.25. The results indicated that moxifloxacin was almost as active as trovafloxacin, as active as gatifloxacin, and more active than levofloxacin and ciprofloxacin against the anaerobes tested.
采用在威尔肯斯 - 查尔格伦肉汤中进行的肉汤微量稀释技术，评估了莫西沙星和其他七种抗生素（其中四种为喹诺酮类）对292株专性厌氧菌的抗菌活性。莫西沙星的MIC50/MIC90值（mg/l）如下：脆弱拟杆菌（n = 62）为0.25/2，卵形拟杆菌（n = 70）为1/4，普通拟杆菌（n = 29）为0.25/1，多形拟杆菌（n = 17）为2/2，粪拟杆菌（n = 11）为1/2，普雷沃菌属（n = 11）为0.25/2，梭杆菌属（n = 17）为1/4，沃兹沃思嗜胆菌（n = 29）为0.5/1，梭菌属（n = 29）为0.125/0.5。解脲拟杆菌（n = 8）和消化链球菌属（n = 9）的MIC50值（mg/l）为0.25。结果表明，在测试针对厌氧菌方面，莫西沙星的活性几乎与曲伐沙星相同，与加替沙星相当，且比左氧氟沙星和环丙沙星更具活性。
