机构收容的智障患者中乙肝疫苗免疫的持续时间

Duration of immunity to hepatitis B vaccination in institutionalized mentally retarded patients.

作者信息

Torre D, Broggini M, Botta V, Sampietro C

机构信息

Division of Infectious Diseases Regional Hospital and Foundation E. and S. Macchi, Varese, Italy.

出版信息

Vaccine. 1989 Apr;7(2):102-3. doi: 10.1016/0264-410x(89)90044-3.

DOI:10.1016/0264-410x(89)90044-3

PMID:2526418

Abstract

Susceptible individuals of an institution for the mentally retarded (20 residents and six staff members) were vaccinated with Hevac B Pasteur (5 micrograms, months 0, 1, 2, 14). There were protective levels of anti-HBs in 75% of residents and 100% of staff members after 15 months from the first dose of the vaccine. After a 4-year follow-up period, there were persistent and protective levels of anti-HBs in 80% of residents, compared with 66% in staff members. In addition, no clinical hepatitis B infections were observed during this period.

摘要

一家智障机构的易感人群（20名居民和6名工作人员）接种了巴斯德公司的Hevac B疫苗（5微克，分别在第0、1、2、14个月接种）。在接种首剂疫苗15个月后，75%的居民和100%的工作人员体内抗-HBs水平达到保护水平。经过4年的随访期，80%的居民体内抗-HBs水平持续且处于保护水平，而工作人员中这一比例为66%。此外，在此期间未观察到临床乙型肝炎感染病例。