微小RNA-30a通过靶向骨巨细胞瘤中的RunX2抑制骨溶解。
MiR-30a inhibits osteolysis by targeting RunX2 in giant cell tumor of bone.
作者信息
Huang Quan, Jiang Zhengyu, Meng Tong, Yin Huabin, Wang Jing, Wan Wei, Cheng Mo, Yan Wangjun, Liu Tielong, Song Dianwen, Chen Haiyan, Wu Zhipeng, Xu Wei, Li Zhenxi, Zhou Wang, Xiao Jianru
机构信息
Department of Bone Tumor Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Division of Rheumatology, Zhongda Hospital, Dongnan University, Nanjing, China.
出版信息
Biochem Biophys Res Commun. 2014 Oct 10;453(1):160-5. doi: 10.1016/j.bbrc.2014.09.076. Epub 2014 Sep 27.
RunX2 has been identified to crucially regulate the osteolysis in giant cell tumor of bone. MiR-30a is an intronic miRNA identified as tumor suppressor, but little is known about its role in giant tumor cell of bone. In our research, we reported miR-30a was down-regulated in GCT whereas RunX2 was highly expressed. Further research proved that miR-30a can regulate the expression of RunX2 by binding to its 3'-UTR, which influence the osteoclast differentiation and osteolysis formation. Thus, these results suggest that miR-30a could directly target RunX2 and participate in osteolysis in GCT.
RunX2已被确定在骨巨细胞瘤的骨溶解过程中起关键调节作用。MiR-30a是一种被鉴定为肿瘤抑制因子的内含子miRNA，但对其在骨巨细胞瘤中的作用知之甚少。在我们的研究中，我们报道miR-30a在骨巨细胞瘤中表达下调，而RunX2高表达。进一步的研究证明，miR-30a可通过与RunX2的3'-UTR结合来调节其表达，从而影响破骨细胞分化和骨溶解形成。因此，这些结果表明miR-30a可直接靶向RunX2并参与骨巨细胞瘤的骨溶解过程。
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