miR-126-5p 通过抑制 MMP-13 调节破骨细胞分化和巨细胞瘤骨吸收。
MiR-126-5p regulates osteoclast differentiation and bone resorption in giant cell tumor through inhibition of MMP-13.
机构信息
Department of Bone Tumor Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Division of Rheumatology, Zhongda Hospital, Dongnan University, Nanjing, China.
出版信息
Biochem Biophys Res Commun. 2014 Jan 17;443(3):944-9. doi: 10.1016/j.bbrc.2013.12.075. Epub 2013 Dec 19.
Giant cell tumor (GCT) of bone is an aggressive skeletal tumor characterized by localized bone resorption. Matrix metalloproteinase-13 (MMP-13) is the principal proteinase expressed by the stromal cells of GCT (GCTSCs) and also considered to play a crucial role in formation of the osteolytic lesion in GCT. However, the exact mechanism of the regulation of MMP-13 expression in GCTSCs was unknown. In this study, we identified miR-126-5p was significantly downregulated in GCTSCs and affect osteoclast (OC) differentiation and bone resorption by repressing MMP-13 expression at the post-transcriptional level. Thus, our studies show that miR-126-5p plays an important physiological role in multinucleated giant cell formation and osteolytic lesion in GCT.
骨巨细胞瘤（GCT）是一种侵袭性骨骼肿瘤，其特征为局部骨质吸收。基质金属蛋白酶-13（MMP-13）是 GCT 基质细胞（GCTSCs）表达的主要蛋白酶，也被认为在 GCT 的溶骨性病变形成中发挥关键作用。然而，GCTSCs 中 MMP-13 表达的调控的确切机制尚不清楚。在这项研究中，我们发现 miR-126-5p 在 GCTSCs 中显著下调，并通过在转录后水平抑制 MMP-13 的表达来影响破骨细胞（OC）分化和骨质吸收。因此，我们的研究表明 miR-126-5p 在 GCT 中的多核巨细胞形成和溶骨性病变中发挥重要的生理作用。
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