Department of Respiratory Diseases, Jing'an District Centre Hospital of Shanghai (Huashan Hospital Fudan University Jing'an Branch), Xikang Road 259#, Jing'an District, Shanghai 200040, China.
Department of Respiratory Diseases, ChangHai Hospital, Second Military Medical University, Changhai Road 168#, Yangpu District, Shanghai 200433, China.
Biochem Biophys Res Commun. 2015 Jan 9;456(2):549-54. doi: 10.1016/j.bbrc.2014.09.074. Epub 2014 Sep 27.
Hyperoxic acute lung injury (HALI) is a clinical syndrome as a result of prolonged supplement of high concentrations of oxygen. Previous studies have shown hyperbaric oxygen preconditioning (HBO-PC) had a protective effect on oxidative injury. In the present study, we investigated the effect of HBO-PC on HALI in rats. The results demonstrated that HBO-PC ameliorated the lung biochemical and histological alterations induced by hyperoxia, decreased oxidative products but increased antioxidant enzymes. Furthermore, HBO-PC up-regulated heme oxygenase-1 (HO-1) mRNA and activity in lung tissues. The administration of HO-1 inhibitor, Zinc protoporphyrin IX, abolished its protective effects. The data showed that HBO-PC could protect rats against HALI and the anti-oxidative effect may be related to the up-regulation of HO-1.
高氧性急性肺损伤（HALI）是一种由于长时间补充高浓度氧气而导致的临床综合征。先前的研究表明，高压氧预处理（HBO-PC）对氧化损伤具有保护作用。在本研究中，我们研究了 HBO-PC 对大鼠 HALI 的影响。结果表明，HBO-PC 改善了由高氧引起的肺生化和组织学改变，降低了氧化产物，但增加了抗氧化酶。此外，HBO-PC 上调了肺组织中的血红素加氧酶-1（HO-1）mRNA 和活性。给予 HO-1 抑制剂锌原卟啉 IX 可消除其保护作用。这些数据表明，HBO-PC 可以保护大鼠免受 HALI 的侵害，其抗氧化作用可能与 HO-1 的上调有关。
