• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
In vivo visualization of the development of the enteric nervous system using a Tg(-8.3bphox2b:Kaede) transgenic zebrafish.使用Tg(-8.3bphox2b:Kaede)转基因斑马鱼对肠神经系统发育进行体内可视化。
Genesis. 2014 Dec;52(12):985-90. doi: 10.1002/dvg.22826. Epub 2014 Nov 4.
2
Depletion of the IKBKAP ortholog in zebrafish leads to hirschsprung disease-like phenotype.斑马鱼中IKBKAP直系同源物的缺失会导致类先天性巨结肠症表型。
World J Gastroenterol. 2015 Feb 21;21(7):2040-6. doi: 10.3748/wjg.v21.i7.2040.
3
Defining the transcriptomic landscape of the developing enteric nervous system and its cellular environment.定义发育中的肠神经系统及其细胞环境的转录组图谱。
BMC Genomics. 2017 Apr 12;18(1):290. doi: 10.1186/s12864-017-3653-2.
4
Endoderm-derived Sonic hedgehog and mesoderm Hand2 expression are required for enteric nervous system development in zebrafish.内胚层来源的音猬因子和中胚层Hand2的表达是斑马鱼肠道神经系统发育所必需的。
Dev Biol. 2008 Jun 1;318(1):52-64. doi: 10.1016/j.ydbio.2008.02.061. Epub 2008 Mar 20.
5
Molecular fingerprinting delineates progenitor populations in the developing zebrafish enteric nervous system.分子指纹识别描绘了发育中的斑马鱼肠道神经系统中的祖细胞群体。
Dev Dyn. 2016 Nov;245(11):1081-1096. doi: 10.1002/dvdy.24438. Epub 2016 Sep 21.
6
lessen encodes a zebrafish trap100 required for enteric nervous system development.lessen编码一种斑马鱼中肠神经系统发育所需的trap100。
Development. 2006 Feb;133(3):395-406. doi: 10.1242/dev.02215. Epub 2006 Jan 5.
7
Phox2b function in the enteric nervous system is conserved in zebrafish and is sox10-dependent.Phox2b在斑马鱼肠道神经系统中的功能是保守的，且依赖于sox10。
Mech Dev. 2005 May;122(5):659-69. doi: 10.1016/j.mod.2004.12.008. Epub 2005 Jan 13.
8
Zebrafish: an exciting model for investigating the spatio-temporal pattern of enteric nervous system development.斑马鱼：一种用于研究肠道神经系统发育时空模式的令人兴奋的模型。
Pediatr Surg Int. 2010 Dec;26(12):1217-21. doi: 10.1007/s00383-010-2746-7. Epub 2010 Oct 24.
9
Establishment of a transgenic zebrafish EF1α:Kaede for monitoring cell proliferation during regeneration.建立一个转 EF1α:Kaede 基因的斑马鱼，用于监测再生过程中的细胞增殖。
Fish Shellfish Immunol. 2013 May;34(5):1390-4. doi: 10.1016/j.fsi.2013.02.021. Epub 2013 Mar 5.
10
Embryonic fate map of first pharyngeal arch structures in the sox10: kaede zebrafish transgenic model.sox10:kaede斑马鱼转基因模型中第一咽弓结构的胚胎命运图谱。
J Craniofac Surg. 2012 Sep;23(5):1333-7. doi: 10.1097/SCS.0b013e318260f20b.

引用本文的文献

1
Going with the Flow: Sensorimotor Integration Along the Zebrafish GI Tract.顺应自然：斑马鱼胃肠道的感觉运动整合
Cells. 2025 Jul 30;14(15):1170. doi: 10.3390/cells14151170.
2
genes affect neuronal differentiation in the developing zebrafish enteric nervous system.基因影响发育中的斑马鱼肠道神经系统中的神经元分化。
Proc Natl Acad Sci U S A. 2025 Aug 19;122(33):e2510548122. doi: 10.1073/pnas.2510548122. Epub 2025 Aug 11.
3
Enteric neural crest development in Astyanax mexicanus surface fish and cavefish.墨西哥丽脂鲤（Astyanax mexicanus）表层鱼和洞穴鱼的肠神经嵴发育
Differentiation. 2025 Jun 13;144:100881. doi: 10.1016/j.diff.2025.100881.
4
BMP signaling pathway member expression is enriched in enteric neural progenitors and required for zebrafish enteric nervous system development.骨形态发生蛋白（BMP）信号通路成员的表达在肠神经祖细胞中富集，并且是斑马鱼肠神经系统发育所必需的。
Dev Dyn. 2025 Mar;254(3):272-287. doi: 10.1002/dvdy.737. Epub 2024 Sep 19.
5
A targeted CRISPR-Cas9 mediated F0 screen identifies genes involved in establishment of the enteric nervous system.靶向 CRISPR-Cas9 介导的 F0 筛选鉴定参与肠神经系统建立的基因。
PLoS One. 2024 May 29;19(5):e0303914. doi: 10.1371/journal.pone.0303914. eCollection 2024.
6
A targeted CRISPR-Cas9 mediated F0 screen identifies genes involved in establishment of the enteric nervous system.一项靶向CRISPR-Cas9介导的F0筛选鉴定出参与肠神经系统建立的基因。
bioRxiv. 2023 Dec 29:2023.12.28.573581. doi: 10.1101/2023.12.28.573581.
7
Genetic regulation of enteric nervous system development in zebrafish.斑马鱼肠道神经系统发育的遗传调控。
Biochem Soc Trans. 2024 Feb 28;52(1):177-190. doi: 10.1042/BST20230343.
8
Unbiased characterization of the larval zebrafish enteric nervous system at a single cell transcriptomic level.在单细胞转录组水平上对斑马鱼幼体肠道神经系统进行无偏表征。
iScience. 2023 Jun 8;26(7):107070. doi: 10.1016/j.isci.2023.107070. eCollection 2023 Jul 21.
9
In toto imaging of early enteric nervous system development reveals that gut colonization is tied to proliferation downstream of Ret.全肠道成像揭示了早期肠神经系统的发育，表明肠道定植与 Ret 下游的增殖有关。
Development. 2022 Nov 1;149(21). doi: 10.1242/dev.200668. Epub 2022 Oct 31.
10
A dynamic and expandable digital 3D-atlas maker for monitoring the temporal changes in tissue growth during hindbrain morphogenesis.用于监测后脑形态发生过程中组织生长的时间变化的动态可扩展数字 3D 图谱制作器。
Elife. 2022 Sep 28;11:e78300. doi: 10.7554/eLife.78300.

本文引用的文献

1
Development and developmental disorders of the enteric nervous system.肠神经系统的发育和发育障碍。
Nat Rev Gastroenterol Hepatol. 2013 Jan;10(1):43-57. doi: 10.1038/nrgastro.2012.234. Epub 2012 Dec 11.
2
The enteric nervous system and neurogastroenterology.肠神经系统与神经胃肠病学。
Nat Rev Gastroenterol Hepatol. 2012 Mar 6;9(5):286-94. doi: 10.1038/nrgastro.2012.32.
3
BAPTI and BAPTISM birthdating of neurons in zebrafish.
Cold Spring Harb Protoc. 2012 Jan 1;2012(1):87-92. doi: 10.1101/pdb.prot067520.
4
Development of the zebrafish enteric nervous system.斑马鱼肠道神经系统的发育
Methods Cell Biol. 2011;101:143-60. doi: 10.1016/B978-0-12-387036-0.00006-2.
5
Asymmetrical distribution of non-conserved regulatory sequences at PHOX2B is reflected at the ENCODE loci and illuminates a possible genome-wide trend.PHOX2B处非保守调控序列的不对称分布在ENCODE基因座上得以体现，并揭示了一种可能的全基因组趋势。
BMC Genomics. 2009 Jan 7;10:8. doi: 10.1186/1471-2164-10-8.
6
Functional development of the enteric nervous system--from migration to motility.肠道神经系统的功能发育——从迁移到蠕动
Neurogastroenterol Motil. 2008 May;20 Suppl 1:20-31. doi: 10.1111/j.1365-2982.2008.01098.x.
7
Critical numbers of neural crest cells are required in the pathways from the neural tube to the foregut to ensure complete enteric nervous system formation.从神经管到前肠的通路中需要关键数量的神经嵴细胞，以确保完整的肠神经系统形成。
Development. 2008 May;135(9):1681-91. doi: 10.1242/dev.017418. Epub 2008 Apr 2.
8
Metrics of sequence constraint overlook regulatory sequences in an exhaustive analysis at phox2b.在对phox2b进行详尽分析时，序列约束指标忽略了调控序列。
Genome Res. 2008 Feb;18(2):252-60. doi: 10.1101/gr.6929408. Epub 2007 Dec 10.
9
The Tol2kit: a multisite gateway-based construction kit for Tol2 transposon transgenesis constructs.Tol2试剂盒：一种基于多位点Gateway技术的用于构建Tol2转座子转基因构建体的试剂盒。
Dev Dyn. 2007 Nov;236(11):3088-99. doi: 10.1002/dvdy.21343.
10
Evaluating the biological relevance of putative enhancers using Tol2 transposon-mediated transgenesis in zebrafish.利用Tol2转座子介导的转基因技术在斑马鱼中评估假定增强子的生物学相关性。
Nat Protoc. 2006;1(3):1297-305. doi: 10.1038/nprot.2006.230.

使用Tg(-8.3bphox2b:Kaede)转基因斑马鱼对肠神经系统发育进行体内可视化。

In vivo visualization of the development of the enteric nervous system using a Tg(-8.3bphox2b:Kaede) transgenic zebrafish.

作者信息

Harrison Colin, Wabbersen Tara, Shepherd Iain T

机构信息

Department of Biology, Emory University, Atlanta, Georgia.

出版信息

Genesis. 2014 Dec;52(12):985-90. doi: 10.1002/dvg.22826. Epub 2014 Nov 4.

DOI:10.1002/dvg.22826
PMID:25264359
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5804488/
Abstract

The phox2b gene encodes a transcription factor that is expressed in the developing enteric nervous system (ENS). An enhancer element has been identified in the zebrafish phox2b locus that can drive tissue specific expression of reporter genes in enteric neuron precursor cells. We have generated a transgenic zebrafish line in which the Kaede fluorescent protein is under the control of this phox2b enhancer. This line has stable expression of the Kaede protein in enteric neuron precursor cells over three generations. To demonstrate the utility of this line we compared the migration and division rates of enteric neuron precursor cells in wild type and the zebrafish ENS mutant lessen.

摘要

phox2b基因编码一种在发育中的肠神经系统（ENS）中表达的转录因子。在斑马鱼phox2b基因座中已鉴定出一种增强子元件，它可以驱动报告基因在肠神经元前体细胞中进行组织特异性表达。我们构建了一种转基因斑马鱼品系，其中Kaede荧光蛋白受该phox2b增强子的控制。该品系在三代以上的肠神经元前体细胞中具有稳定的Kaede蛋白表达。为了证明该品系的实用性，我们比较了野生型和斑马鱼ENS突变体lessen中肠神经元前体细胞的迁移和分裂速率。