益生菌对儿童食物过敏的预防作用：一项随机对照试验的荟萃分析。
Probiotics' preventive effect on pediatric food allergy: a meta-analysis of randomized controlled trials.
作者信息
Kong Xiang-yi, Yang Yi, Guan Jian, Wang Ren-zhi
机构信息
Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
出版信息
Chin Med Sci J. 2014 Sep;29(3):144-7. doi: 10.1016/s1001-9294(14)60059-6.
OBJECTIVE
To investigate the preventive effect of probiotics on pediatric food allergy.
METHODS
From MEDLINE bibliographical database, we searched and reviewed all randomized controlled trials on the preventive effects of probiotics on pediatric food allergies up to September 2013 and excluded the studies that do not meet inclusion criteria and extracted the data. Meta-analysis for the results of homogenous studies was performed using RevMan 5.0 and the co-effect was pooled by using fixed-effects model of relative risk (RR) ratios.
RESULTS
Ten trials published between 2007 and 2012 including 2701 cases were included. Meta-analysis based on included data showed that the preventive effect of prenatal and postnatal probiotic supplementation on food allergies was not significant with the RR=0.88 (95% CI: 0.76-1.03).
CONCLUSION
Present evidences cannot show in unequivocal terms that prenatal and postnatal probiotic supplementation will prevent food allergic diseases.
目的
探讨益生菌对儿童食物过敏的预防作用。
方法
从MEDLINE文献数据库中，检索并回顾了截至2013年9月所有关于益生菌对儿童食物过敏预防作用的随机对照试验，排除不符合纳入标准的研究并提取数据。使用RevMan 5.0对同质研究结果进行Meta分析，并采用相对危险度（RR）比值的固定效应模型合并效应量。
结果
纳入了2007年至2012年发表的10项试验，共2701例病例。基于纳入数据的Meta分析显示，产前和产后补充益生菌对食物过敏的预防作用不显著，RR = 0.88（95%CI：0.76 - 1.03）。
结论
目前的证据不能明确表明产前和产后补充益生菌能预防食物过敏性疾病。
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