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土曲霉中土霉素途径的分子遗传特征。

Molecular genetic characterization of terreic acid pathway in Aspergillus terreus.

机构信息

Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California , Los Angeles, California 90089, United States.

出版信息

Org Lett. 2014 Oct 17;16(20):5250-3. doi: 10.1021/ol502242a. Epub 2014 Sep 29.

DOI:10.1021/ol502242a
PMID:25265334
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4201328/
Abstract

Terreic acid is a natural product derived from 6-methylsalicylic acid (6-MSA). A compact gene cluster for its biosynthesis was characterized. Isolation of the intermediates and shunt products from the mutant strains, combined with bioinformatic analyses, allowed for the proposition of a biosynthetic pathway for terreic acid.

摘要

土雷酸是一种天然产物，来源于 6-甲基水杨酸（6-MSA）。其生物合成的紧凑基因簇已被鉴定。从突变株中分离出中间体和分流产物，并结合生物信息学分析，提出了土雷酸的生物合成途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff74/4201328/c19ef63810b3/ol-2014-02242a_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff74/4201328/4008c9bf7c83/ol-2014-02242a_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff74/4201328/4faa86222f60/ol-2014-02242a_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff74/4201328/c19ef63810b3/ol-2014-02242a_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff74/4201328/4008c9bf7c83/ol-2014-02242a_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff74/4201328/4faa86222f60/ol-2014-02242a_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff74/4201328/c19ef63810b3/ol-2014-02242a_0003.jpg

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