Miller J F, Morahan G, Allison J
Immunol Today. 1989 Feb;10(2):53-7. doi: 10.1016/0167-5699(89)90306-X.
Transgenic technology allows the introduction into the germline of an animal of a known gene coding for a normally foreign antigen, and by means of a specific promoter, the direction of its expression to specific tissues. The antigen is therefore synthesized by the animal as an authentic self molecule, at a particular stage in development, and in a particular site. In this review, J.F.A.P. Miller and colleagues discuss this radically new approach to the investigation of the mechanism of acquired immunological tolerance to self components.
转基因技术能够将编码通常为外来抗原的已知基因导入动物的生殖系，并借助特定启动子将其表达导向特定组织。因此，该抗原在动物发育的特定阶段、特定部位作为真正的自身分子被合成。在这篇综述中，J.F.A.P. 米勒及其同事讨论了这种全新的方法，用于研究获得性免疫耐受自身成分机制。
