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利用肥大细胞缺陷型w/wv和sl/sld品系小鼠制备大量产生抗大鼠IgE单克隆抗体的杂交瘤。

Production of large numbers of hybridomas producing monoclonal antibodies against rat IgE using mast cell-deficient w/wv and sl/sld strains of mice.

作者信息

Rup B J

机构信息

Immunoinflammatory Diseases Research, G.D. Searle/Monsanto Co., Chesterfield, MO 63198.

出版信息

J Immunol Methods. 1989 Aug 15;122(1):137-42. doi: 10.1016/0022-1759(89)90344-x.

DOI:10.1016/0022-1759(89)90344-x
PMID:2527273
Abstract

A number of different mouse strains and immunization protocols were used to attempt to make monoclonal antibodies against rat IgE for use in studies of the structure, biological activities and regulation of this class of antibody. Successful production of large numbers of monoclonal antibodies was achieved when mast cell deficient (w/wv and sl/sld) but not conventional (BALB/c, CAF1 or SJL) mice were used. These results suggest that the poor response of conventional strains of mice to rat IgE may be due to the presence of mast cells bearing high affinity receptors for IgE in these mice.

摘要

使用了多种不同的小鼠品系和免疫方案，试图制备抗大鼠IgE的单克隆抗体，用于研究这类抗体的结构、生物学活性及调控。当使用肥大细胞缺陷型（w/wv和sl/sld）而非传统型（BALB/c、CAF1或SJL）小鼠时，成功产生了大量单克隆抗体。这些结果表明，传统品系小鼠对大鼠IgE反应不佳可能是由于这些小鼠中存在带有IgE高亲和力受体的肥大细胞。

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