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Efficient production of syngeneic anti-IgE monoclonal antibodies with high affinity and diverse specificity.

作者信息

Haba S, Nisonoff A

机构信息

Rosenstiel Research Center, Department of Biology, Brandeis University, Waltham, MA 02254, USA.

出版信息

J Immunol Methods. 1995 Jun 28;183(2):199-209. doi: 10.1016/0022-1759(95)00056-g.

DOI:10.1016/0022-1759(95)00056-g
PMID:7602144
Abstract

Syngeneic monoclonal anti-IgE antibodies are of value in studies of the suppression of IgE synthesis. Procedures are described here for the production of high titers of murine anti-IgE antibodies by initiating immunization in the perinatal period, before mice develop tolerance to their autologous IgE. This in turn facilitates the production of monoclonal anti-IgE antibodies. Properties of some of these mAbs are reported, including affinity, fine specificity and ability to bind to IgE on B lymphoma cells or mast cells.

摘要

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