多草药配方冲明汤可改善老年小鼠的空间记忆，并增加其齿状回中的细胞生成。
The multi-herbal formula Chong-Myung-Tang improves spatial memory and increases cell genesis in the dentate gyrus of aged mice.
作者信息
Liu Lei, Zhang Mingwei, Zhang Ruifen, Lee Mira, Wang Zhen, Hou Jingang, Sung Chang-Keun
机构信息
a Key Laboratory of Functional Food , Ministry of Agriculture, Sericultural and Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences , Guangzhou , P.R. China.
出版信息
Biosci Biotechnol Biochem. 2014;78(10):1710-5. doi: 10.1080/09168451.2014.930319. Epub 2014 Jun 26.
Chong-Myung-Tang (CMT) is a multi-herbal formula that has been used to improve memory. However, the potential mechanism remains unknown. The present study investigated the effects of CMT (50, 100, and 200 mg/kg) on spatial memory of aged mice. The behavioral training tests indicated that 200 mg/kg CMT treatment can significantly improve spatial memory of aged mice in the Morris water maze. Moreover, cell survival was examined by injecting bromodeoxyuridine (BrdU) on the first three days. The result showed that 200 mg/kg CMT treatment significantly increased cell survival in the dentate gyrus. Cell proliferation was determined by injecting BrdU 2 h before the mice were killed. The result suggested that CMT treatments had no influence on cell proliferation in the dentate gyrus. Thus, an increase in cell survival in the dentate gyrus stimulated by CMT may be involved in the effect of CMT on spatial memory improvement.
菖蒲汤（CMT）是一种用于改善记忆力的多草药配方。然而，其潜在机制尚不清楚。本研究调查了CMT（50、100和200mg/kg）对老年小鼠空间记忆的影响。行为训练测试表明，200mg/kg CMT处理可显著改善老年小鼠在莫里斯水迷宫中的空间记忆。此外，在前三天注射溴脱氧尿苷（BrdU）来检测细胞存活情况。结果显示，200mg/kg CMT处理显著增加了齿状回中的细胞存活。在处死小鼠前2小时注射BrdU来测定细胞增殖。结果表明，CMT处理对齿状回中的细胞增殖没有影响。因此，CMT刺激齿状回中细胞存活的增加可能与CMT改善空间记忆的作用有关。
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