Litarczek G, Tulbure D, Rădan A, Moţoiu I, Funduc I, Gayraud A, Oftez L, Dumitriu A
Rev Chir Oncol Radiol O R L Oftalmol Stomatol Chir. 1989 Jan-Feb;38(1):69-80.
The study attempted to evaluate the effects of anesthesia and of surgical interventions on certain humoral and cellular components of the mechanism of specific immunity. A total of 64 patients suffering with benign and malignant affections of the stomach and of the colon that had underwent resections under general anesthesia of the hypnoanalgesia type were followed at three stages of their evolution--before surgery, at 24 hours after surgery, and 7 days after surgery. Blood samples were obtained for performing the following tests: count of lymphocytes, blastic transformations test, stimulated control (with PHA and PWM), rosetting test, total number of eosinophils, high affinity eosinophils, and other tests. Electrophoretic fractions, total serum proteins, and dosage of IgG, IgM, and IgA immunoglobulins were also measured. A total of 24 tests have been performed. The patients were investigated both globally and according to sex, type of affection (malignant, or other), and by age. The results indicated a depression of the majority of the results of tests excepting those which detect precursor B, and T-helper cells, which showed a stimulation. Differentiated behaviours were also noted in the various groups with regard to the intensity of the reaction, although not with its direction.
该研究试图评估麻醉和手术干预对特异性免疫机制中某些体液和细胞成分的影响。共有64例患有胃和结肠良恶性疾病的患者，在催眠镇痛型全身麻醉下接受了切除术，并在其病程的三个阶段进行跟踪——术前、术后24小时和术后7天。采集血样进行以下检测：淋巴细胞计数、母细胞转化试验、刺激对照（用PHA和PWM）、玫瑰花结试验、嗜酸性粒细胞总数、高亲和力嗜酸性粒细胞以及其他检测。还测量了电泳组分、总血清蛋白以及IgG、IgM和IgA免疫球蛋白的含量。总共进行了24项检测。对患者进行了全面调查，并按性别、疾病类型（恶性或其他）和年龄进行了分类调查。结果表明，除了检测前体B细胞和辅助性T细胞的检测结果显示有刺激作用外，大多数检测结果都出现了抑制。尽管反应方向没有差异，但在不同组中也观察到了反应强度的差异行为。
