Sun S D, Zhang Q, Zhao X W, Tang J
Sheng Li Xue Bao. 1989 Feb;41(1):56-62.
In order to investigate the interaction between atrial natriuretic factor (ANF) and arginine vasopressin (AVP) in the pathogenesis of essential hypertension, the effects of intravenous (iv) or intracerebroventricular (icv) injection of human ANF-(99-126) on plasma and brain AVP, as well as mean arterial pressure (MAP), urinary volume (UV) and sodium (UNaV) excretion in stroke-prone spontaneously hypertensive rats (SHRsp) and age-matched normotensive Wistar-Kyoto rats (WKY) were studied. The results showed that ten minutes after iv injection of ANF, MAP decreased by 9.4% and 12.2% (P less than 0.05), UV increased about 9 and 20 folds (P less than 0.01), UNaV increased about 16 and 29 folds (P less than 0.01) in SHRsp and WKY rats, respectively. No such significant changes in these parameters were found in the icv group. Although iv and icv injection of ANF caused significant decrease of plasma AVP in both strains, the decrease was less marked in SHRsp than in WKY rats, while the maximum decreases were 58% (iv) and 31% (icv) in SHRsp, the corresponding values were 80% (iv) and 65% (icv) in WKY. Intravenous and intracerebroventricular injection of ANF also induced significant increase of hypothalamic AVP in both SHRsp and WKY rats, but no significant change could be found in hypophyseal AVP content. The results suggest that decreased sensitivity of AVP inhibition as well as less marked hypotensive, diuretic and natriuretic effects to ANF in SHRsp might play a role in the pathogenesis of their hypertension.
为了研究心房利钠因子（ANF）与精氨酸加压素（AVP）在原发性高血压发病机制中的相互作用，研究了静脉注射（iv）或脑室内注射（icv）人ANF-（99-126）对易患中风的自发性高血压大鼠（SHRsp）和年龄匹配的正常血压Wistar-Kyoto大鼠（WKY）的血浆和脑AVP、平均动脉压（MAP）、尿量（UV）和尿钠排泄（UNaV）的影响。结果显示，静脉注射ANF十分钟后，SHRsp和WKY大鼠的MAP分别下降了9.4%和12.2%（P<0.05），UV分别增加了约9倍和20倍（P<0.01），UNaV分别增加了约16倍和29倍（P<0.01）。脑室内注射组这些参数无明显变化。虽然静脉注射和脑室内注射ANF均导致两种品系大鼠血浆AVP显著降低，但SHRsp大鼠的降低幅度小于WKY大鼠，SHRsp大鼠静脉注射和脑室内注射的最大降幅分别为58%和31%，WKY大鼠相应的值分别为80%（静脉注射）和65%（脑室内注射）。静脉注射和脑室内注射ANF也诱导SHRsp和WKY大鼠下丘脑AVP显著增加，但垂体AVP含量无明显变化。结果表明，SHRsp大鼠对AVP抑制的敏感性降低以及对ANF的降压、利尿和利钠作用不明显可能在其高血压发病机制中起作用。
