Lapiński M, Stepniakowski K, Januszewicz A, Noszczyk B, Szczepańska-Sadowska E
Department of Clinical and Applied Physiology, Medical Academy of Warsaw, Poland.
J Physiol Pharmacol. 1992 Mar;43(1):65-78.
The aim of the study was to find out whether vasopressin (AVP) modifies hypotensive and heart rate accelerating effects of atrial natriuretic peptide (ANP) in normotensive (WKY) and spontaneously hypertensive (SHR) conscious rats. The effect of i.v. administration of 1; 2 and 4 micrograms of ANP on blood pressure (MP) and heart rate (HR) was compared during i.v. infusion of 0.9% NaCl (NaCl), NaCl+AVP (1.2 ng kg-1 min-1) and NaCl+dEt2AVP (V1 receptors antagonist, 0.5 microgram kg-1 min-1). AVP increased MP in SHR and WKY and decreased HR in SHR. V1 antagonist decreased MP and increased HR only in SHR. In SHR ANP decreased MP and increased HR during NaCl, AVP and V1 antagonist infusion. In WKY these effects were observed only during AVP administration. In each experimental situation hypotension and tachycardia induced by ANP were greater in SHR than in WKY. In both strains ANP induced changes in MP and HR were enhanced during AVP in comparison to NaCl infusion. V1 antagonist did not modify effects of ANP in WKY and SHR. The results indicate that ANP abolishes hypertensive response induced by blood AVP elevation and that the basal levels of endogenous vasopressin acting through V1 receptors does not interfere with hypotensive action of ANP neither in WKY nor in SHR.
本研究旨在探讨在正常血压（WKY）和自发性高血压（SHR）清醒大鼠中，血管加压素（AVP）是否会改变心房利钠肽（ANP）的降压和心率加快作用。在静脉输注0.9%氯化钠（NaCl）、NaCl+AVP（1.2 ng kg-1 min-1）和NaCl+dEt2AVP（V1受体拮抗剂，0.5 microgram kg-1 min-1）期间，比较静脉注射1、2和4微克ANP对血压（MP）和心率（HR）的影响。AVP使SHR和WKY的MP升高，使SHR的HR降低。V1拮抗剂仅使SHR的MP降低、HR升高。在SHR中，输注NaCl、AVP和V1拮抗剂期间，ANP使MP降低、HR升高。在WKY中，仅在给予AVP期间观察到这些效应。在每种实验情况下，SHR中由ANP诱导的低血压和心动过速比WKY更明显。与输注NaCl相比，在两种品系中，AVP存在时ANP诱导的MP和HR变化均增强。V1拮抗剂未改变WKY和SHR中ANP的作用。结果表明，ANP可消除血液中AVP升高诱导的高血压反应，且通过V1受体起作用的内源性血管加压素基础水平在WKY和SHR中均不干扰ANP的降压作用。
