青光眼和构象障碍中的免疫现象：为何另一只眼未受累？
Immune phenomena in glaucoma and conformational disorders: why is the second eye not involved?
作者信息
Kuehn Markus H
机构信息
Department of Ophthalmology and Visual Sciences, The University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242.
出版信息
J Glaucoma. 2014 Oct-Nov;23(8 Suppl 1):S59-61. doi: 10.1097/IJG.0000000000000115.
Abstract
Data along several lines of evidence have suggested that a systemic autoimmune response may be provoked in glaucoma and could contribute to retinal ganglion cell loss. If such an autoimmune response exists, one could predict that in cases of unilateral glaucoma, autoantibodies generated would affect both eyes, leading to damage in the unaffected, contralateral eye in an intraocular pressure-independent manner. However, such an effect has not yet been reported. There are currently no data to reconcile these contrasting observations but a review of the literature suggests a possible explanation.
摘要
多项证据表明，青光眼可能引发全身性自身免疫反应，并可能导致视网膜神经节细胞丢失。如果存在这种自身免疫反应，可以预测，在单侧青光眼病例中，产生的自身抗体会影响双眼，以与眼压无关的方式导致未受影响的对侧眼受损。然而，尚未有此类影响的报道。目前尚无数据来协调这些相互矛盾的观察结果，但文献综述提出了一种可能的解释。
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