剥脱综合征的动物模型：现状与未来
Animal models of exfoliation syndrome, now and future.
作者信息
John Simon W M, Harder Jeffrey M, Fingert John H, Anderson Michael G
机构信息
*The Howard Hughes Medical Institute †The Jackson Laboratory, Bar Harbor, ME ‡Department of Ophthalmology, Tufts University School of Medicine, Boston, MA Departments of §Ophthalmology and Visual Sciences ∥Molecular Physiology and Biophysics, University of Iowa ¶Center for the Prevention and Treatment of Visual Loss, Iowa City VA Health Care System, Iowa City, IA.
出版信息
J Glaucoma. 2014 Oct-Nov;23(8 Suppl 1):S68-72. doi: 10.1097/IJG.0000000000000121.
Abstract
At present, no animal models fully embody exfoliation syndrome or exfoliation glaucoma. Both genetic and environmental factors appear critical for disease manifestation, and both must be considered when generating animal models. Because mice provide a powerful mammalian platform for modeling complex disease, this paper focuses on mouse models of exfoliation syndrome and exfoliation glaucoma.
摘要
目前，尚无动物模型能完全体现剥脱综合征或剥脱性青光眼。遗传因素和环境因素对疾病表现似乎都至关重要，在构建动物模型时必须同时考虑这两者。由于小鼠为模拟复杂疾病提供了一个强大的哺乳动物平台，本文重点关注剥脱综合征和剥脱性青光眼的小鼠模型。
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