Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA.
Invest Ophthalmol Vis Sci. 2012 Sep 21;53(10):6427-33. doi: 10.1167/iovs.12-10085.
We examined the association between caffeine and caffeinated beverage consumption in relation to the risk of exfoliation glaucoma or exfoliation glaucoma suspect (EG/EGS).
We followed 78,977 women from the Nurses' Health Study (NHS) and 41,202 men from the Health Professionals Follow-up Study (HPFS) who were at least 40 years of age, did not have glaucoma, and reported undergoing eye examinations from 1980 (NHS) or 1986 (HPFS) to 2008. Information on consumption of caffeine-containing beverages and potential confounders were repeatedly ascertained in validated follow-up questionnaires. Confirmation with medical record review revealed 360 incident EG/EGS cases. Multivariate rate ratios (RRs) for EG/EGS were calculated in each cohort and then pooled using meta-analytic techniques.
Compared with participants whose cumulatively updated total caffeine consumption was <125 mg/day, participants who consumed ≥ 500 mg/day had a trend toward increased risk of EG/EGS that was not statistically significant (RR = 1.43; 95% confidence interval [CI], 0.98-2.08); P trend = 0.06). Compared to abstainers, those who drank ≥ 3 cups of caffeinated coffee daily were at increased risk of EG/EGS (RR = 1.66; 95% CI, 1.09-2.54; P trend = 0.02). These results were not materially altered after adjustment for total fluid intake. Associations were stronger among women with a family history of glaucoma (P interaction = 0.06 for coffee; P interaction = 0.03 for caffeine). We did not find associations with consumption of other caffeinated products (caffeinated soda, caffeinated tea, decaffeinated coffee or chocolate) and risk of EG/EGS (P trend ≥ 0.31).
We observed a positive association between heavier coffee consumption with risk of EG/EGS in this large prospective study.
我们研究了咖啡因和含咖啡因饮料的摄入与剥脱性青光眼或剥脱性青光眼疑似患者（EG/EGS）风险之间的关系。
我们随访了来自护士健康研究（NHS）的 78977 名女性和来自健康专业人员随访研究（HPFS）的 41202 名男性，这些人年龄至少为 40 岁，没有青光眼，并报告在 1980 年（NHS）或 1986 年（HPFS）至 2008 年期间接受过眼部检查。在反复确认的随访问卷中，我们获取了关于含咖啡因饮料的摄入情况和潜在混杂因素的信息。通过医疗记录审查确认了 360 例 EG/EGS 病例。在每个队列中计算 EG/EGS 的多变量率比（RR），然后使用荟萃分析技术进行汇总。
与累积更新的总咖啡因摄入量<125mg/天的参与者相比，摄入量≥500mg/天的参与者 EG/EGS 的风险呈增加趋势，但无统计学意义（RR=1.43；95%置信区间[CI]，0.98-2.08；P趋势=0.06）。与不饮酒者相比，每天饮用≥3 杯含咖啡因咖啡的参与者 EG/EGS 的风险增加（RR=1.66；95%CI，1.09-2.54；P趋势=0.02）。调整总液体摄入量后，这些结果没有明显改变。在有青光眼家族史的女性中，关联更强（咖啡 P 交互作用=0.06；咖啡因 P 交互作用=0.03）。我们没有发现与其他含咖啡因产品（含咖啡因苏打水、含咖啡因茶、脱咖啡因咖啡或巧克力）的摄入与 EG/EGS 风险之间存在关联（P 趋势≥0.31）。
在这项大型前瞻性研究中，我们观察到更大量的咖啡饮用与 EG/EGS 风险之间存在正相关。
