心房利钠因子（99 - 126）对缺水绵羊的肾脏影响

Renal effects of atrial natriuretic factor (99-126) in water-deprived sheep.

Yates N A, Coghlan J P, Scoggins B A, McDougall J G

Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1989 May;16(5):433-7. doi: 10.1111/j.1440-1681.1989.tb01582.x.

Abstract

The renal response to renal arterial infusion of synthetic human atrial natriuretic factor (ANF) (99-126) at 50 micrograms/h was examined in conscious sheep dehydrated by 48 h water deprivation and was compared with the response of normally hydrated animals. 2. Renal arterial infusion of ANF produced increases in the excretion of Na, K, Ca and urine in both dehydrated and normally hydrated animals, although the effect was significantly blunted in dehydrated animals compared with normally hydrated animals. 3. The attenuation of renal effects of ANF in dehydrated animals is probably due to the negative sodium and/or fluid balance of the dehydrated animals.

摘要

对经48小时禁水造成脱水的清醒绵羊，研究了以50微克/小时的速率肾动脉输注合成人心房利钠因子（ANF）（99 - 126）的肾脏反应，并与正常水合状态动物的反应进行比较。2. 肾动脉输注ANF使脱水和正常水合状态的动物的钠、钾、钙排泄及尿量均增加，尽管与正常水合状态动物相比，脱水动物的这种作用明显减弱。3. 脱水动物中ANF肾脏效应的减弱可能归因于脱水动物的负钠和/或液体平衡。