Wang Y, Zhou J, Zhang Y, Wang L, Liu Y, Fan L, Zhu J, Xu X, Huang G, Li X, Xun W
Department of Plastic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
Oral Dis. 2015 May;21(4):432-6. doi: 10.1111/odi.12294. Epub 2015 Jan 12.
To determine the role of PRDM1, a key molecule for modulating the immune cells, in Warthin tumour (WT) pathogenesis.
Forty paraffin-embedded parotid tissues of patients (mean age: 62.08 ± 11.90) with WT were retrieved from the pathology archives of Qindu Hospital from January 2012 to December 2012. The PRDM1 expression was investigated in a cohort of WT by immunohistochemistry.
PRDM1 was expressed only on the epithelial component but not on ectopic lymphoid tissue of the tumour. Statistically, PRDM1 expression rates between WT glandular epithelial cells (40/40 cases) and the tumour-adjacent tissues (0/9 cases), and WT germinal centres (0/34 cases) and tonsil tissues (10/10 cases) were significantly different (P < 0.001), respectively.
The PRDM1 expression appeared to play an essential role in WT pathogenesis. A better understanding of it might give options for revealing possible novel management strategies.
