Department of Family Medicine, Gachon University Gil Medical Center, 1198 Guwol-dong, Namdong-gu, Incheon, 405-760, Republic of Korea,
J Endocrinol Invest. 2014 Nov;37(11):1117-20. doi: 10.1007/s40618-014-0182-6. Epub 2014 Oct 4.
It is important to identify a 'metabolically unhealthy obese' subset with higher cardiovascular risk among obese individuals. We investigated the associations between the GNB3 C825T polymorphism and obesity-related metabolic risk factors among Korean obese women.
This study was a sub-investigation of a double-blind randomized controlled trial that examined the additive effect of or list at on weight loss with sibutramine. A sample of 111 obese women were divided into T-carriers (CT/TT) or a homozygous CC group, according to the presence of the 825T allele at GNB3. These groups were compared to determine their associations with obesity-related metabolic risk factors, i.e., fasting plasma glucose, serum lipids, serum insulin/insulin resistance, and abdominal fat amounts.
The allele frequencies of the GNB3 polymorphism were C allele = 59.5% and T allele = 40.5%. The T allele was found to be significantly associated with greater visceral fat and higher serum lipids, and these significances remained robust after adjusting for potential covariates.
The GNB3 825T polymorphism is significantly associated with greater visceral fat and higher serum lipids in Korean obese women and it suggests that the GNB3 C825T is a determinant of obesity-related metabolic traits in this population.
在肥胖人群中，确定具有更高心血管风险的“代谢不健康肥胖”亚组非常重要。我们研究了 GNB3 C825T 多态性与韩国肥胖女性肥胖相关代谢危险因素之间的关系。
本研究是一项双盲随机对照试验的子研究，该试验检查了 sibutramine 对体重减轻的附加作用或列表作用。根据 GNB3 中 825T 等位基因的存在，将 111 名肥胖女性分为 T 携带者（CT/TT）或纯合 CC 组。比较这些组以确定它们与肥胖相关代谢危险因素的关系，即空腹血糖、血脂、血清胰岛素/胰岛素抵抗和腹部脂肪量。
GNB3 多态性的等位基因频率为 C 等位基因=59.5%和 T 等位基因=40.5%。发现 T 等位基因与更大的内脏脂肪和更高的血脂显著相关，这些显著性在调整潜在协变量后仍然稳健。
GNB3 825T 多态性与韩国肥胖女性更大的内脏脂肪和更高的血脂显著相关，这表明 GNB3 C825T 是该人群肥胖相关代谢特征的决定因素。
