Pluznick Jennifer L, Caplan Michael J
Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland; and.
Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut
Clin J Am Soc Nephrol. 2015 Sep 4;10(9):1626-35. doi: 10.2215/CJN.00730114. Epub 2014 Oct 3.
In order to assess the status of the volume and composition of the body fluid compartment, the kidney monitors a wide variety of chemical and physical parameters. It has recently become clear that the kidney's sensory capacity extends well beyond its ability to sense ion concentrations in the forming urine. The kidney also keeps track of organic metabolites derived from a surprising variety of sources and uses a complex interplay of physical and chemical sensing mechanisms to measure the rate of fluid flow in the nephron. Recent research has provided new insights into the nature of these sensory mechanisms and their relevance to renal function.
为了评估体液区室的容量和成分状况，肾脏会监测各种各样的化学和物理参数。最近已经明确，肾脏的感觉能力远远超出了其感知正在形成的尿液中离子浓度的能力。肾脏还会追踪源自各种惊人来源的有机代谢物，并利用物理和化学传感机制的复杂相互作用来测量肾单位中的液体流速。最近的研究为这些传感机制的性质及其与肾功能的相关性提供了新的见解。
