Genc Mine, Genc Berhan, Cengiz Hakan
Department of Obstetrics and Gynecology, Şifa University School of Medicine, Fevzipaşa Bulvarı No:172/2, 35240, Basmane/Izmir, Turkey,
Arch Gynecol Obstet. 2015 Apr;291(4):877-81. doi: 10.1007/s00404-014-3498-8. Epub 2014 Oct 4.
The aim of the present study is to determine the potential risk factors for adenomyosis and to investigate its relationship with accompanying gynecological pathologies and clinical characteristics.
This study is a retrospective analysis of 945 patients who underwent hysterectomy between May 2005 and January 2013 at the Sifa University Medical Faculty Hospital, Clinic of Obstetrics and Gynecology. The study included 327 patients with adenomyosis and 618 patients without adenomyosis by histopathological examination of the uterus.
There was a significant positive correlation between development of adenomyosis and presence of leiomyoma (p < 0.0001), history of previous abortion (p < 0.0001), history of previous pregnancy (p = 0.0002), and normal body mass index (p < 0.0001). However, no significant relationship existed between development of adenomyosis and smoking (p > 0.4300), normal delivery (p = 0.9600), cesarean delivery (p = 0.5705), endometrial hyperplasia (p = 0.1721), or ovarian endometriosis (p = 0.8595).
Women who are multiparous have leiomyoma, a previous history of abortion, and a normal body mass index are at increased risk for development of adenomyosis. Adenomyosis might be one cause of unexplained recurrent spontaneous abortion during pregnancy.
本研究旨在确定子宫腺肌病的潜在危险因素，并探讨其与伴随的妇科病理及临床特征之间的关系。
本研究是对2005年5月至2013年1月在锡法大学医学院医院妇产科诊所接受子宫切除术的945例患者进行的回顾性分析。通过对子宫进行组织病理学检查，研究纳入了327例子宫腺肌病患者和618例无子宫腺肌病患者。
子宫腺肌病的发生与子宫肌瘤的存在（p < 0.0001）、既往流产史（p < 0.0001）、既往妊娠史（p = 0.0002）以及正常体重指数（p < 0.0001）之间存在显著正相关。然而，子宫腺肌病的发生与吸烟（p > 0.4300）、顺产（p = 0.9600）、剖宫产（p = 0.5705）、子宫内膜增生（p = 0.1721）或卵巢子宫内膜异位症（p = 0.8595）之间不存在显著关系。
多产、患有子宫肌瘤、有既往流产史且体重指数正常的女性患子宫腺肌病的风险增加。子宫腺肌病可能是孕期不明原因复发性自然流产的原因之一。
