Parazzini F, Vercellini P, Panazza S, Chatenoud L, Oldani S, Crosignani P G
Centro Medicina della Riproduzione, I Clinica Ostetrico Ginecologica Università di Milano, Italy.
Hum Reprod. 1997 Jun;12(6):1275-9. doi: 10.1093/humrep/12.6.1275.
In order to analyse risk factors for adenomyosis, 707 consecutive women who underwent hysterectomy between January 1993 and June 1994 at the Clinica Luigi Mangiagalli, Milan, Italy, were interviewed before surgery by trained physicians. Information on the presence of adenomyosis was obtained from pathologic records. Out of the 707 women, adenomyosis was identified in 150 subjects (21.2%). Women who smoked tended to be at decreased risk of the condition: in comparison with women who had never smoked, the risk for current smokers was 0.7 (0.3-1.3) and the risk decreased with number of cigarettes smoked per day, the odds ratios being 0.8 and 0.6 respectively in women reporting fewer than 10 and more than 10 cigarette smoked per day (chi2 trend 3.57, P = 0.06). The frequency of adenomyosis was higher in parous women: in comparison with nulliparae, the odds ratio of the disease were 1.8 [95% confidence interval (CI) 0.9-3.4] and 3.1 (95% CI 1.7-5.5) respectively in women reporting one and two or more births (chi2 trend 20.71, P < 0.01). Likewise, women reporting one or more spontaneous abortions had an odds ratio of 1.7 (95% CI 1.1-2.6) for adenomyosis, in comparison with those reporting no spontaneous abortion.
为了分析子宫腺肌病的风险因素，1993年1月至1994年6月期间，在意大利米兰的Clinica Luigi Mangiagalli接受子宫切除术的707名连续女性患者，在手术前由经过培训的医生进行了访谈。子宫腺肌病的存在信息从病理记录中获取。在这707名女性中，150名受试者（21.2%）被诊断为子宫腺肌病。吸烟女性患该病的风险往往较低：与从不吸烟的女性相比，当前吸烟者的风险为0.7（0.3 - 1.3），且风险随每日吸烟量的增加而降低，每日吸烟少于10支和多于10支的女性的优势比分别为0.8和0.6（卡方趋势3.57，P = 0.06）。经产妇子宫腺肌病的发生率更高：与未生育女性相比，报告生育1次和2次或更多次的女性患该病的优势比分别为1.8 [95%置信区间（CI）0.9 - 3.4]和3.1（95% CI 1.7 - 5.5）（卡方趋势20.71，P < 0.01）。同样，与报告无自然流产的女性相比，报告有1次或更多次自然流产的女性患子宫腺肌病的优势比为1.7（95% CI 1.1 - 2.6）。
