Thakore Sonal, Rathore Puran Singh, Jadeja Ravirajsinh N, Thounaojam Menaka, Devkar Ranjitsinh V
Department of Chemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara 390002, Gujarat, India.
Department of Chemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara 390002, Gujarat, India.
Mater Sci Eng C Mater Biol Appl. 2014 Nov;44:209-15. doi: 10.1016/j.msec.2014.08.019. Epub 2014 Aug 11.
In this work, sunflower oil was utilized for the biomimetic synthesis of silver (Ag) nanoparticles (NPs), leading to highly mono-dispersed hexagonal-shaped silver nanoparticles (NPs) at various concentrations. It was found that the biomolecules of the oil not only have the capability to reduce silver ions, due to its extended phenolic system, but also appear to recognize and affect the Ag nanocrystal growth on the (110) face, leading to hexagonal growth of the NPs of 50 nm size. Initially, some spherical AgNPs of less than 10nm diameter were observed; however, over a longer period of time, a majority of hexagonal-shaped nanocrystals were formed. The one step synthesis can be extended for other metals. The as prepared sunflower oil capped AgNPs being completely free of toxic chemicals can be directly utilized for in vitro studies and offer a more rational approach for cellular applications. The NP solution exhibited dose-dependent cytotoxicity in human lung carcinoma cells and physiologically relevant cell model (3T3L1 cells).
在这项工作中，向日葵油被用于银（Ag）纳米颗粒（NPs）的仿生合成，从而在不同浓度下得到了高度单分散的六边形银纳米颗粒（NPs）。研究发现，油中的生物分子不仅因其扩展的酚类体系而具有还原银离子的能力，而且似乎能够识别并影响（110）面上的银纳米晶体生长，从而导致50纳米尺寸的纳米颗粒呈六边形生长。最初，观察到一些直径小于10纳米的球形AgNP；然而，经过更长时间后，形成了大多数六边形纳米晶体。这种一步合成法可扩展用于其他金属。所制备的以向日葵油包覆的AgNP完全不含有毒化学物质，可直接用于体外研究，并为细胞应用提供了一种更合理的方法。该纳米颗粒溶液在人肺癌细胞和生理相关细胞模型（3T3L1细胞）中表现出剂量依赖性细胞毒性。
