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帕金森病的味觉障碍。

Taste in Parkinson's disease.

机构信息

Department of Neurological and Movement Sciences, Anatomy and Histology Section, University of Verona, Strada le Grazie, 8, 37134, Verona, Italy,

出版信息

J Neurol. 2015;262(4):806-13. doi: 10.1007/s00415-014-7518-1. Epub 2014 Oct 4.

DOI:10.1007/s00415-014-7518-1
PMID:25280862
Abstract

Parkinson's disease is now considered a complex systemic disease also characterized by the occurrence of a variety of non-motor symptoms. Among them, a chemosensory impairment defined as a deficient olfactory performance is now acknowledged to be one of the prevalent symptoms since the early stages of the disease. Less clear are the incidence, extent and pathophysiology of taste function. The purpose of the present review is to summarize the state of the art in taste literature. To provide a better understanding of the available results, we will also discuss the different methods for taste evaluation and the other potential confounders to be addressed by future research.

摘要

帕金森病现在被认为是一种复杂的系统性疾病,其特征还包括多种运动外症状的发生。其中,一种化学感觉障碍,即嗅觉表现不佳,现已被认为是疾病早期的常见症状之一。味觉功能的发生率、程度和病理生理学尚不清楚。本文综述的目的是总结味觉研究的现状。为了更好地理解现有结果,我们还将讨论味觉评估的不同方法和未来研究中需要解决的其他潜在混杂因素。

相似文献

1
Taste in Parkinson's disease.帕金森病的味觉障碍。
J Neurol. 2015;262(4):806-13. doi: 10.1007/s00415-014-7518-1. Epub 2014 Oct 4.
2
Know thyself: Exploring interoceptive sensitivity in Parkinson's disease.认识你自己:探索帕金森病中的内感受敏感性。
J Neurol Sci. 2016 May 15;364:110-5. doi: 10.1016/j.jns.2016.03.019. Epub 2016 Mar 12.
3
Molecular and Genetic Factors Involved in Olfactory and Gustatory Deficits and Associations with Microbiota in Parkinson's Disease.涉及帕金森病嗅觉和味觉减退的分子和遗传因素及其与微生物组的关联。
Int J Mol Sci. 2021 Apr 20;22(8):4286. doi: 10.3390/ijms22084286.
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Early impairment of cognitive functions in Parkinson's disease.帕金森病认知功能的早期损害
Arq Neuropsiquiatr. 2007 Jun;65(2B):406-10. doi: 10.1590/s0004-282x2007000300008.
5
Motor features in Parkinson's disease with normal olfactory function.帕金森病患者嗅觉功能正常的运动特征。
Mov Disord. 2016 Sep;31(9):1414-7. doi: 10.1002/mds.26687. Epub 2016 Jun 9.
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Comprehensive identification of delusions and olfactory, tactile, gustatory, and minor hallucinations in Parkinson's disease psychosis.全面识别帕金森病精神病中的妄想和嗅觉、触觉、味觉及轻度幻觉。
Parkinsonism Relat Disord. 2018 Sep;54:40-45. doi: 10.1016/j.parkreldis.2018.04.008. Epub 2018 Apr 4.
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Neural correlates of taste perception in congenital olfactory impairment.
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Olfaction and taste in Parkinson's disease: the association with mild cognitive impairment and the single cognitive domain dysfunction.帕金森病的嗅觉和味觉:与轻度认知障碍和单一认知领域功能障碍的关联。
J Neural Transm (Vienna). 2019 May;126(5):585-595. doi: 10.1007/s00702-019-01996-z. Epub 2019 Mar 25.
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Perceptual abnormalities in Parkinson's disease: top-down or bottom-up processes?帕金森病中的感知异常:自上而下还是自下而上的过程?
Perception. 1995;24(10):1201-21. doi: 10.1068/p241201.
10
The relationship between the grooved pegboard test and clinical motor symptom evaluation across the spectrum of Parkinson's disease severity.在帕金森病严重程度的整个范围内,沟纹钉板测试与临床运动症状评估之间的关系。
J Parkinsons Dis. 2012;2(3):207-13. doi: 10.3233/JPD-2012-012093.

引用本文的文献

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Editorial for a New Section: Nutrition and Neuro Sciences.新栏目社论:营养与神经科学
Nutrients. 2025 Apr 22;17(9):1399. doi: 10.3390/nu17091399.
2
Taste impairment in patients with Parkinsonism.帕金森病患者的味觉障碍
J Neurol. 2025 Mar 1;272(3):238. doi: 10.1007/s00415-025-12983-8.
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Chemosensory Impairments and Their Impact on Nutrition in Parkinson's Disease: A Narrative Literature Review.化学感觉障碍及其对帕金森病营养状况的影响:一篇叙述性文献综述

本文引用的文献

1
Taste performance in Parkinson’s disease.帕金森病患者的味觉表现。
J Neural Transm (Vienna). 2014 Feb;121(2):119-22. doi: 10.1007/s00702-013-1089-7.
2
Sweet liking in patients with Parkinson's disease.帕金森病患者的甜味喜好。
J Neurol Sci. 2013 Jun 15;329(1-2):17-22. doi: 10.1016/j.jns.2013.03.005. Epub 2013 Apr 3.
3
Olfactory dysfunction: common in later life and early warning of neurodegenerative disease.嗅觉功能障碍:常见于老年期,是神经退行性疾病的早期预警信号。
Nutrients. 2025 Feb 13;17(4):671. doi: 10.3390/nu17040671.
4
Insights into salt perception and cognitive impairment among middle-aged and older adults: a scoping review.中年及老年人对盐的感知与认知障碍的见解:一项范围综述
BMC Public Health. 2025 Feb 22;25(1):728. doi: 10.1186/s12889-025-21852-y.
5
Decreased Tongue-Lip Motor Function in Japanese Population with Low Taste Sensitivity: A Cross-Sectional Study.味觉敏感度低的日本人群舌唇运动功能减退:一项横断面研究。
J Clin Med. 2024 Aug 11;13(16):4711. doi: 10.3390/jcm13164711.
6
The Association Between Neurocognitive Disorders and Gustatory Dysfunction: A Systematic Review and Meta-Analysis.神经认知障碍与味觉障碍的关系:系统评价和荟萃分析。
Neuropsychol Rev. 2024 Mar;34(1):192-213. doi: 10.1007/s11065-023-09578-3. Epub 2023 Feb 20.
7
D2/D3 Receptor Agonism: Paving the Way for a New Therapeutic Target for Taste Disorders in Parkinson's Disease and Other Conditions?D2/D3 受体激动剂:为帕金森病和其他疾病的味觉障碍的新治疗靶点铺平道路?
Int J Neuropsychopharmacol. 2022 Nov 17;25(11):933-935. doi: 10.1093/ijnp/pyac042.
8
Enhanced Taste Recognition Following Subacute Treatment With The Dopamine D2/D3 Receptor Agonist Pramipexole in Healthy Volunteers.健康志愿者亚急性使用多巴胺 D2/D3 受体激动剂普拉克索后味觉识别能力增强。
Int J Neuropsychopharmacol. 2022 Sep 28;25(9):720-726. doi: 10.1093/ijnp/pyac030.
9
Umami and Other Taste Perceptions in Patients With Parkinson's Disease.帕金森病患者的鲜味及其他味觉感知
J Mov Disord. 2022 May;15(2):115-123. doi: 10.14802/jmd.21058. Epub 2022 Mar 22.
10
Unpleasant olfactory and gustatory stimuli increase pain unpleasantness in patients with chronic oral burning pain: An exploratory study.不愉快的嗅觉和味觉刺激会增加慢性口腔灼痛患者的疼痛不适:一项探索性研究。
Eur J Pain. 2022 May;26(5):1094-1106. doi: 10.1002/ejp.1933. Epub 2022 Mar 17.
Dtsch Arztebl Int. 2013 Jan;110(1-2):1-7, e1. doi: 10.3238/arztebl.2013.0001. Epub 2013 Jan 7.
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Characteristics of taste disorders.味觉障碍的特征。
Eur Arch Otorhinolaryngol. 2013 May;270(6):1855-60. doi: 10.1007/s00405-012-2310-2. Epub 2012 Dec 11.
5
Non-motor symptoms of Parkinson's disease: the patient's perspective.帕金森病的非运动症状:患者视角。
J Neural Transm (Vienna). 2013 Apr;120(4):531-5. doi: 10.1007/s00702-012-0928-2. Epub 2012 Dec 7.
6
Olfactory dysfunction in Parkinson disease.帕金森病的嗅觉功能障碍。
Nat Rev Neurol. 2012 May 15;8(6):329-39. doi: 10.1038/nrneurol.2012.80.
7
Smell and taste disorders.嗅觉和味觉障碍。
GMS Curr Top Otorhinolaryngol Head Neck Surg. 2011;10:Doc04. doi: 10.3205/cto000077. Epub 2012 Apr 26.
8
Evaluation of electrogustometry and the filter paper disc method for taste assessment.用于味觉评估的电味觉测量法和滤纸圆盘法的评价
Acta Otolaryngol. 2011 May;131(5):488-93. doi: 10.3109/00016489.2010.535850. Epub 2011 Mar 10.
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Taste function in patients with Parkinson disease.帕金森病患者的味觉功能。
J Neurol. 2011 Jun;258(6):1076-9. doi: 10.1007/s00415-010-5884-x. Epub 2010 Dec 31.
10
A study about the frequency of taste disorders.一项关于味觉障碍频率的研究。
J Neurol. 2011 Mar;258(3):386-92. doi: 10.1007/s00415-010-5763-5. Epub 2010 Oct 1.